PDF(Pubmed)
Abstract：
Skin is a diverse ecosystem that provides a habitat for microorganisms. The skin condition and the skin microbiome interact each other under diverse environmental conditions. This study was conducted on 10 study participants for a one-year, from September 2020 to August 2021, to investigate the variability of skin microbiome and skin biophysical parameters [TEWL, hydration, and elasticity (R5)] according to season, and to understand the interplay between skin microbiome and skin characteristics. We identified that Cutibacterium, Corynebacterium, Staphyloccocus, unclassified genus within Neisseriaceae, and Streptococcus were major skin microbial taxa at the genus level, and fluctuated with the seasons. Cutibacterium was more abundant in winter, while Corynebacterium, Staphylococcus, and Streptococcus were more abundant in summer. Notably, Cutibacterium and skin barrier parameter, TEWL, exhibited a co-decreasing pattern from winter to summer and showed a significant association between Cutibacterium and TEWL. Furthermore, functional profiling using KEGG provided clues on the impact of Cutibacterium on the host skin barrier. This study enhances our understanding of the skin microbiome and its interplay with skin characteristics and highlights the importance of seasonal dynamics in shaping skin microbial composition.
摘要：
皮肤是一个多样化的生态系统，为微生物提供了栖息地。皮肤状况和皮肤微生物组在不同的环境条件下相互作用。这项研究对10名研究参与者进行了为期一年的研究，从2020年9月到2021年8月，调查皮肤微生物组和皮肤生物物理参数的变异性[TEWL，水合作用,和弹性(R5)]根据季节，并了解皮肤微生物组和皮肤特征之间的相互作用。我们确定了Cuutbacterium,棒状杆菌,葡萄球菌,奈瑟菌科内未分类属，链球菌是属水平的主要皮肤微生物类群，随着季节的变化而波动。Cutibacterium在冬天更丰富，而棒状杆菌，葡萄球菌,夏季链球菌含量较高。值得注意的是,镰刀菌和皮肤屏障参数，TEWL,从冬季到夏季表现出共同减少的模式，并且显示出在Cutubacterium和TEWL之间的显着关联。此外，使用KEGG进行功能分析提供了有关Cutubacterium对宿主皮肤屏障的影响的线索。这项研究增强了我们对皮肤微生物组及其与皮肤特征相互作用的理解，并强调了季节性动态在塑造皮肤微生物组成中的重要性。
