UNASSIGNED: The suppositories were all smooth and white. They all had a weight that averaged less than 5 %. The formulations showed a pH between 6 and 6.5. The active ingredient content ranged between 79.666 ± 8.54 % and 99.67 ± 6.55 %. Suppository stiffness was between 2.74 ± 0.04 and 4.20 ± 0.03. The decomposition time of the suppositories varied between 11.25 ± 0.15 to 20.19 ± 0.08 min. The deformation time was between 26.11 ± 0.06 to 38.59 ± 0.47 min. Cabergoline content was released over 45 min from formulations of F10 (∼46 %), F2 (∼64 %), F6 (∼69 %), F4 (∼79 %), F1 (∼88 %), and F7 (∼93 %). However, other formulations released more than 95 % within 45 min.
UNASSIGNED: All variables except melting time significantly affected our responses. In vitro studies have indicated that the optimized cabergoline formula could be an excellent alternative to cabergoline oral formulations.
■栓剂都是光滑和白色的。它们都具有平均小于5%的重量。制剂显示pH在6和6.5之间。活性成分含量介于79.666±8.54%和99.67±6.55%之间。栓剂硬度在2.74±0.04和4.20±0.03之间。栓剂的分解时间在11.25±0.15至20.19±0.08分钟之间变化。变形时间在26.11±0.06至38.59±0.47分钟之间。卡麦角林的含量在45分钟内从F10的配方中释放(〜46%),F2(~64%),F6(~69%),F4(~79%),F1(~88%),和F7(~93%)。然而,其他制剂在45分钟内释放超过95%。
■除熔化时间外的所有变量都显着影响我们的响应。体外研究表明,优化的卡麦角林配方可能是卡麦角林口服制剂的极好替代品。