PDF(Pubmed)
Abstract：
Spinal Cord Injury (SCI) refers to complete or incomplete damage to the spinal cord, which comprises the central nervous system. SCI in dogs, like humans, is mostly caused by external trauma, and the degree of impact is dependent on the location of the injury in the spine. Stem cell therapy is a promising avenue for SCI research. In this report, we investigate the therapeutic potential of amniotic fluid-derived mesenchymal stem cells (AF-MSCs) in dogs with spinal cord injuries. A 2-year-old male beagle dog presented with sensory and motor incomplete symptoms resulting in an inability to control the legs, hips, and genitourinary system due to an injury in the lumbar region of the spinal cord. In addition to the administration of surgical decompression, AF-MSCs were directly injected into the damaged spinal tissue. Approximately 15-16 weeks after stem cell transplantation, the dog\'s hind limb movement improved, and spinal cord regeneration was confirmed through magnetic resonance imaging (MRI). Eventually, the dog was able to walk independently, although not perfectly. In conclusion, AF-MSC-based stem cell transplantation may be beneficial for SCIs.
摘要：
脊髓损伤（SCI）是指脊髓的完全或不完全损伤，包括中枢神经系统。SCI在狗中，像人类一样，主要是由外部创伤引起的,影响程度取决于脊柱损伤的位置。干细胞疗法是SCI研究的一个有希望的途径。在这份报告中,我们研究了羊水间充质干细胞（AF-MSCs）在犬脊髓损伤中的治疗潜力。一只2岁的雄性比格犬出现感觉和运动不完全症状，导致腿部无法控制，臀部,和泌尿生殖系统由于脊髓腰部区域的损伤。除了手术减压，将AF-MSCs直接注射到受损的脊髓组织中。干细胞移植后约15-16周，狗的后肢运动得到改善，通过磁共振成像（MRI）证实脊髓再生。最终,这只狗能够独立行走，虽然不完美。总之,基于AF-MSC的干细胞移植可能对SCI有益。
