PDF(Pubmed)
Abstract：
Introduction The phenomenon of coronavirus disease 2019 (COVID-19)-related candidiasis is gaining increased attention and acknowledgment as an integral component of the severe consequences of COVID-19. The aim of the present study was to assess the association between Candida albicans and COVID-19 in complete denture wearers. Materials and methods An observational study was conducted on 45 complete denture wearers, who were divided into three groups as follows: Group 1, 15 subjects with mild to moderate COVID-19 infection; Group 2, 15 subjects with severe COVID-19 infection; and Group 3, 15 subjects without COVID-19 infection. Mean colony forming units (CFU) were observed on agar plates containing Sabouraud dextrose in the salivary samples of the participants. Analysis of variance, followed by post-hoc analysis by Tukey\'s test, was used to compare CFU between the groups. Pearson\'s correlation coefficient was used to study the correlation between variables. Results The highest average colony-forming units of Candida albicans were observed in Group 2, followed by Group 1, compared to the control group, and a significant (p<0.001) difference was found. A weak positive correlation was found between the age of the patients and the duration of denture usage, as well as between age and the counts of Candida albicans in Groups 1 and 3. This correlation was more pronounced in Group 3. A strong positive correlation was observed in all groups between the Candida albicans count and the duration of denture usage by the patients. Conclusion The association between Candida albicans and denture wear was compounded by the presence of COVID-19. Consequently, the timely identification of Candida albicans infection in patients with COVID-19 is important to establish more efficacious approaches for antifungal treatment and prophylactic interventions.
摘要：
简介2019年冠状病毒病（COVID-19）相关的念珠菌病现象越来越受到关注和认可，这是COVID-19严重后果的一个组成部分。本研究的目的是评估白色念珠菌和COVID-19在全口义齿佩戴者中的相关性。材料与方法对45名全口义齿佩戴者进行了观察性研究，他们分为以下三组：第1组，15名轻度至中度COVID-19感染的受试者；第2组，15名重度COVID-19感染的受试者；第3组，15名无COVID-19感染的受试者。在参与者的唾液样品中，在含有Sabouraud葡萄糖的琼脂平板上观察到平均菌落形成单位（CFU）。方差分析，接下来是Tukey测试的事后分析，用于比较各组之间的CFU。采用皮尔逊相关系数研究变量间的相关性。结果与对照组相比,第2组白色念珠菌平均菌落形成单位最高,第1组次之,并且发现显著(p<0.001)差异。发现患者的年龄与义齿使用时间之间存在弱正相关，以及年龄与第1组和第3组的白色念珠菌计数之间。这种相关性在第3组中更为明显。在所有组中，白色念珠菌计数与患者使用义齿的持续时间之间均呈强正相关。结论COVID-19的存在加剧了白色念珠菌与义齿磨损之间的关联。因此,及时识别COVID-19患者的白色念珠菌感染对于建立更有效的抗真菌治疗和预防性干预措施非常重要.
