PDF(Pubmed)
Abstract：
UNASSIGNED: Primary breast lymphoma (PBL) is a very rare form of non-Hodgkin\'s lymphoma (NHL). A primary T-cell lymphoma in the breast with no previously identified lymphomatous lesions is an even rarer form of this malignancy.
UNASSIGNED: A biopsy of a breast mass in a 60-year-old Caucasian man showed a morphologic-immunophenotypic profile with features characteristic of an ALK-positive (AKT+), anaplastic large cell lymphoma. Fluorescence in situ hybridization (FISH) analysis of fixed, paraffin-embedded tissue of this lesion was performed at our institution for IRF4/DUSP22 gene rearrangement. No rearrangement was detected. The patient presented with mutations in the following genes; BCOR_p.Q600X, DNMT3A_p.F609fs, NOTCH1_p.P2320fs, and IDH2_p.R140Q. However, the patient\'s consultation was complicated by the fact that he had been diagnosed with breast cancer at a local hospital and had come to our institution for further consultation. The histology findings were confirmed by immunohistochemistry and FISH. Computed tomography and positron emission tomography did not reveal nodules elsewhere in the body, which allowed the staging of the patient to be completed. However, although the patient had previously received the chemotherapy CCOP regimen (ie, cyclophosphamide, vincristine, prednisolone acetate) he did not go into remission in a timely manner and relapsed after six months, followed by a drastic deterioration in his condition after four months, resulting in his death in less than one month.
UNASSIGNED: This report of a male patient describes a case of a rare T-cell lymphoma of the breast that occurs considerably more frequently in female patients. The differential diagnosis of the histology of this tumor showed mutations that occur more often in lymphoblastic lymphoma or leukemia. This rare malignancy and associated mutations led to the death of this patient during treatment.
UNASSIGNED: A biopsy of a breast mass in a 60-year-old Caucasian man showed a morphologic-immunophenotypic profile with features characteristic of an ALK-positive (AKT+), anaplastic large cell lymphoma. Fluorescence in situ hybridization (FISH) analysis of fixed, paraffin-embedded tissue of this lesion was performed at our institution for IRF4/DUSP22 gene rearrangement. No rearrangement was detected. The patient presented with mutations in the following genes; BCOR_p.Q600X, DNMT3A_p.F609fs, NOTCH1_p.P2320fs, and IDH2_p.R140Q. However, the patient\'s consultation was complicated by the fact that he had been diagnosed with breast cancer at a local hospital and had come to our institution for further consultation. The histology findings were confirmed by immunohistochemistry and FISH. Computed tomography and positron emission tomography did not reveal nodules elsewhere in the body, which allowed the staging of the patient to be completed. However, although the patient had previously received the chemotherapy CCOP regimen (ie, cyclophosphamide, vincristine, prednisolone acetate) he did not go into remission in a timely manner and relapsed after six months, followed by a drastic deterioration in his condition after four months, resulting in his death in less than one month.
UNASSIGNED: This report of a male patient describes a case of a rare T-cell lymphoma of the breast that occurs considerably more frequently in female patients. The differential diagnosis of the histology of this tumor showed mutations that occur more often in lymphoblastic lymphoma or leukemia. This rare malignancy and associated mutations led to the death of this patient during treatment.
摘要：
■原发性乳腺淋巴瘤（PBL）是一种非常罕见的非霍奇金淋巴瘤（NHL）。乳腺中没有先前确定的淋巴瘤性病变的原发性T细胞淋巴瘤是这种恶性肿瘤的更罕见形式。
一名60岁白种人的乳腺肿块活检显示，其形态学免疫表型特征为ALK阳性（AKT+），间变性大细胞淋巴瘤.固定的荧光原位杂交（FISH）分析，该病变的石蜡包埋组织在我们机构进行IRF4/DUSP22基因重排.没有检测到重排。患者出现以下基因的突变;BCOR_p。Q600X,DNMT3A_p。F609fs,NOTCH1_p.P2320fs,和IDH2_p。R140Q.然而,病人的会诊很复杂，因为他在当地医院被诊断出患有乳腺癌，并来到我们的机构接受进一步会诊。通过免疫组织化学和FISH证实了组织学发现。计算机断层扫描和正电子发射断层扫描没有发现身体其他部位的结节，这使得患者的分期得以完成。然而,尽管该患者先前曾接受过CCOP化疗方案（即，环磷酰胺,长春新碱,醋酸泼尼松龙)他没有及时缓解，六个月后复发，四个月后他的病情急剧恶化，导致他在不到一个月的时间内死亡。
■这份男性患者的报告描述了一例罕见的乳腺T细胞淋巴瘤，女性患者的发病率更高。该肿瘤组织学的鉴别诊断显示，突变更常见于淋巴母细胞淋巴瘤或白血病。这种罕见的恶性肿瘤和相关突变导致该患者在治疗期间死亡。
一名60岁白种人的乳腺肿块活检显示，其形态学免疫表型特征为ALK阳性（AKT+），间变性大细胞淋巴瘤.固定的荧光原位杂交（FISH）分析，该病变的石蜡包埋组织在我们机构进行IRF4/DUSP22基因重排.没有检测到重排。患者出现以下基因的突变;BCOR_p。Q600X,DNMT3A_p。F609fs,NOTCH1_p.P2320fs,和IDH2_p。R140Q.然而,病人的会诊很复杂，因为他在当地医院被诊断出患有乳腺癌，并来到我们的机构接受进一步会诊。通过免疫组织化学和FISH证实了组织学发现。计算机断层扫描和正电子发射断层扫描没有发现身体其他部位的结节，这使得患者的分期得以完成。然而,尽管该患者先前曾接受过CCOP化疗方案（即，环磷酰胺,长春新碱,醋酸泼尼松龙)他没有及时缓解，六个月后复发，四个月后他的病情急剧恶化，导致他在不到一个月的时间内死亡。
■这份男性患者的报告描述了一例罕见的乳腺T细胞淋巴瘤，女性患者的发病率更高。该肿瘤组织学的鉴别诊断显示，突变更常见于淋巴母细胞淋巴瘤或白血病。这种罕见的恶性肿瘤和相关突变导致该患者在治疗期间死亡。
