Abstract：
UNASSIGNED: Obesity is a risk factor for developing multiple sclerosis (MS) and MS-related disability. The efficacy of behavioral weight loss interventions among people with MS (pwMS) remains largely unknown.
UNASSIGNED: Examine whether a group-based telehealth weight loss intervention produces clinically significant weight loss in pwMS and obesity.
UNASSIGNED: Seventy-one pwMS were randomized to the weight loss intervention or treatment-as-usual (TAU). The 6-month program promoted established guidelines for calorie reduction and increased physical activity. Anthropometric measurements, mobility tasks, self-report questionnaires, and accelerometry were used to assess changes at follow-up.
UNASSIGNED: Mean percent weight loss in the treatment group was 8.6% compared to 0.7% in the TAU group (p < .001). Sixty-five percent of participants in the intervention achieved clinically meaningful weight loss (⩾ 5%). Participants in the treatment group engaged in 46.2 minutes/week more moderate-to-vigorous physical activity than TAU participants (p = .017) and showed improvements in quality of life (p = .012). Weight loss was associated with improved mobility (p = .003) and reduced fatiguability (p = .008).
UNASSIGNED: Findings demonstrate the efficacy of a behavioral intervention for pwMS and obesity, with clinically significant weight loss for two-thirds of participants in the treatment condition. Weight loss may also lead to improved mobility and quality of life.
UNASSIGNED: Examine whether a group-based telehealth weight loss intervention produces clinically significant weight loss in pwMS and obesity.
UNASSIGNED: Seventy-one pwMS were randomized to the weight loss intervention or treatment-as-usual (TAU). The 6-month program promoted established guidelines for calorie reduction and increased physical activity. Anthropometric measurements, mobility tasks, self-report questionnaires, and accelerometry were used to assess changes at follow-up.
UNASSIGNED: Mean percent weight loss in the treatment group was 8.6% compared to 0.7% in the TAU group (p < .001). Sixty-five percent of participants in the intervention achieved clinically meaningful weight loss (⩾ 5%). Participants in the treatment group engaged in 46.2 minutes/week more moderate-to-vigorous physical activity than TAU participants (p = .017) and showed improvements in quality of life (p = .012). Weight loss was associated with improved mobility (p = .003) and reduced fatiguability (p = .008).
UNASSIGNED: Findings demonstrate the efficacy of a behavioral intervention for pwMS and obesity, with clinically significant weight loss for two-thirds of participants in the treatment condition. Weight loss may also lead to improved mobility and quality of life.
摘要：
■肥胖是发生多发性硬化症（MS）和MS相关残疾的危险因素。在MS（pwMS）患者中，行为减肥干预的有效性仍然未知。
■检查基于小组的远程健康减肥干预是否会在pwMS和肥胖症中产生临床上显着的体重减轻。
■将71例pwMS随机分配到体重减轻干预或照常治疗（TAU）。为期6个月的计划促进了减少卡路里和增加体力活动的既定指南。人体测量,移动性任务，自我报告问卷，和加速度测量法用于评估随访时的变化。
与TAU组的0.7%相比,治疗组的平均体重减轻百分比为8.6%(p<.001)。65％的干预参与者实现了临床上有意义的体重减轻（5％）。与TAU参与者相比，治疗组的参与者每周进行46.2分钟的中度至剧烈的体育锻炼（p=0.017），并显示出生活质量的改善（p=0.012）。体重减轻与改善的活动性(p=.003)和降低的疲劳性(p=.008)相关。
■研究结果表明，行为干预对pwMS和肥胖的有效性，在治疗条件下，三分之二的参与者具有临床上显着的体重减轻。体重减轻还可导致改善的活动能力和生活质量。
■检查基于小组的远程健康减肥干预是否会在pwMS和肥胖症中产生临床上显着的体重减轻。
■将71例pwMS随机分配到体重减轻干预或照常治疗（TAU）。为期6个月的计划促进了减少卡路里和增加体力活动的既定指南。人体测量,移动性任务，自我报告问卷，和加速度测量法用于评估随访时的变化。
与TAU组的0.7%相比,治疗组的平均体重减轻百分比为8.6%(p<.001)。65％的干预参与者实现了临床上有意义的体重减轻（
■研究结果表明，行为干预对pwMS和肥胖的有效性，在治疗条件下，三分之二的参与者具有临床上显着的体重减轻。体重减轻还可导致改善的活动能力和生活质量。
