Abstract：
Mesenchymal stem cells (MSCs) have been identified as potential therapeutics for various diseases. In contrast to other sources of MSCs, dental stem cells (DSCs) have received increased attention due to their high activity and easy accessibility. Among them, dental pulp stem cells (DPSCs) exhibit superior self-renewal, multipotency, immunomodulatory, and regenerative capacities. Following their inspiring performance in animal models and clinical trials, DPSCs show pharmacological potential in regenerative medicine. In this review, we have generalized the sources, heterogeneity, and biological characteristics of DPSCs, as well as compared them with other types of dental stem cells. In addition, we summarized the application of DPSCs in digestive diseases (such as liver, esophageal, and intestinal diseases), highlighting their regenerative and pharmacological potential based on the existing preclinical and clinical evidence. Specifically, DPSCs can be> home to injured or inflamed tissues and exert repair and regeneration functions by> facilitating immune regulation, anti-inflammation, and directional differentiation. Although DPSCs have a rosy prospect, future studies should handle the underlying drawbacks and pave the way for the identification of DPSCs as novel regenerative medicine.
摘要：
间充质干细胞（MSC）已被确定为各种疾病的潜在治疗剂。与其他来源的MSC相比，牙科干细胞（DSC）由于其高活性和易于获得而受到越来越多的关注。其中,牙髓干细胞（DPSC）表现出优异的自我更新，多能性，免疫调节,和再生能力。根据他们在动物模型和临床试验中的鼓舞人心的表现，DPSC在再生医学中显示出药理学潜力。在这次审查中,我们已经概括了来源，异质性，和DPSC的生物学特性，以及将它们与其他类型的牙科干细胞进行比较。此外,我们总结了DPSC在消化系统疾病(如肝脏，食道,和肠道疾病)，根据现有的临床前和临床证据，强调其再生和药理潜力。具体来说,DPSC可以是损伤或发炎组织的家园，并通过促进免疫调节发挥修复和再生功能，抗炎，和方向性分化。虽然DPSC有一个美好的前景，未来的研究应该解决潜在的缺陷，并为将DPSCs鉴定为新型再生医学铺平道路。
