OBJECTIVE: Here, we propose that the human body exclusively employs mechanisms of adaptation to protect itself during an adverse event. For this purpose, two control systems are defined, namely the autonomic and the neural control systems. The autonomic control system responds via inflammatory and immune responses, while the neural control system regulates neural signaling, via plastic adaptation. Both systems are proposed to regulate a network of temporal and causative connections which unravel the complex nature of diabetic complications.
RESULTS: A significant result of this approach infers that both systems make DN reversible, thus opening the door to novel therapeutic applications.
目标:这里,我们建议人体在不良事件中专门使用适应机制来保护自己。为此,定义了两个控制系统,即自主和神经控制系统。自主控制系统通过炎症和免疫反应做出反应,而神经控制系统调节神经信号,通过塑料适应。提出了两种系统来调节时间和因果关系的网络,这些网络揭示了糖尿病并发症的复杂性。
结果:这种方法的重要结果推断,两个系统都使DN可逆,从而打开了新的治疗应用的大门。