关键词: Mycobacterium negative pressure wound therapy skin and soft tissue Infection wound

Mesh : Humans Anti-Bacterial Agents / therapeutic use Nontuberculous Mycobacteria Soft Tissue Infections / drug therapy microbiology Negative-Pressure Wound Therapy Skin Diseases, Bacterial / drug therapy Mycobacterium Infections, Nontuberculous / drug therapy microbiology

来  源:   DOI:10.1128/aac.01048-23   PDF(Pubmed)

Abstract:
Nontuberculous mycobacteria (NTM) skin infections remain therapeutically challenging. Given the diversity in infections, host responses, and antimicrobials, clinical guidelines are often built on case series and observational studies. In this commentary, we respond to a paper by Stemkens et al. that introduces an emerging strategy: adjunctive negative pressure wound therapy with instillation and dwell time combined with topical antibiotics for refractory NTM skin and soft tissue infections. We delve into the primary considerations surrounding this innovative approach.
摘要:
非结核性分枝杆菌(NTM)皮肤感染仍然具有治疗挑战性。鉴于感染的多样性,主机响应,和抗菌药物,临床指南通常建立在病例系列和观察性研究的基础上.在这篇评论中,我们回应了Stemkens等人的一篇论文。介绍了一种新兴的策略:滴注和停留时间联合局部抗生素的辅助负压伤口治疗难治性NTM皮肤和软组织感染。我们深入研究围绕这一创新方法的主要考虑因素。
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