PDF(Pubmed)
Abstract：
About 75% cases of post-kala-azar dermal leishmaniasis (PKDL) occur in India. Although the classic description of PKDL is the progression from initial hypopigmented macular lesions to papules to plaques and nodular lesions, atypical morphologies are also seen and are easily missed or misdiagnosed. We report a case of a 27-year-old man who presented to us with multiple acral ulcers and verrucous lesions for 5 years. A diagnosis of PKDL was made based on slit skin smear, histopathology, and quantitative polymerase chain reaction. The patient was given combination therapy with four doses of liposomal amphotericin B and miltefosine 50 mg twice daily for 45 days. In this report, we discuss unusual morphologies of PKDL, the pathway to the diagnosis, and the therapeutic options available along with their efficacy.
摘要：
大约75％的黑热病后真皮利什曼病（PKDL）发生在印度。尽管PKDL的经典描述是从最初的低色素黄斑病变到丘疹到斑块和结节性病变的进展，也可见非典型形态，容易漏诊或误诊。我们报告了一例27岁的男子，他向我们展示了5年的多发性肢端溃疡和疣状病变。根据狭缝皮肤涂片诊断PKDL，组织病理学,和定量聚合酶链反应。患者接受四剂脂质体两性霉素B和50毫克的联合治疗，每天两次，共45天。在这份报告中,我们讨论了PKDL的异常形态，诊断的途径，以及可用的治疗选择及其疗效。
