PDF(Pubmed)
Abstract：
OBJECTIVE: Psoriasis is a chronic, non-contagious autoimmune condition marked by dry, itchy,erythematous and scaly plaques. From modest, localized plaques to total body coverage, the severity of psoriasis varies. Plaque, guttate, inverted, pustular, and erythrodermic psoriasis are the five primary kinds. About 90% of cases are of plaque psoriasis, commonly known as psoriasis vulgaris. Study aims to determine the impact of an rs2228570 (FokI) variant and an rs11568820 (CDX2) variant on serum vitamin D levels (SVD) in patients with psoriasis, and the correlation between the two variants and disease severity.
METHODS: A case-control study consisting of 95 psoriasis vulgaris patients and 84 healthy controls. The clinical investigation, molecular genetics analysis, and biochemical analysis were done for both groups.
RESULTS: SVD levels were significantly decreased in psoriasis patients group. FokI genotypes analysis, we found no significant variance between groups. CDX2 G/G genotype is more prevalent in patients than controls. Moderate psoriasis vulgaris patients with CDX2 G/G genotypes have higher SVD levels than CDX2 G/A, and CDX2 A/A p = 0.003.
CONCLUSIONS: The study found a difference in vitamin D levels between patients and healthy subjects, as well as a difference in vitamin D levels with different FoKI and CDX2 genotypes.
METHODS: A case-control study consisting of 95 psoriasis vulgaris patients and 84 healthy controls. The clinical investigation, molecular genetics analysis, and biochemical analysis were done for both groups.
RESULTS: SVD levels were significantly decreased in psoriasis patients group. FokI genotypes analysis, we found no significant variance between groups. CDX2 G/G genotype is more prevalent in patients than controls. Moderate psoriasis vulgaris patients with CDX2 G/G genotypes have higher SVD levels than CDX2 G/A, and CDX2 A/A p = 0.003.
CONCLUSIONS: The study found a difference in vitamin D levels between patients and healthy subjects, as well as a difference in vitamin D levels with different FoKI and CDX2 genotypes.
摘要：
目的：银屑病是一种慢性，以干燥为特征的非传染性自身免疫性疾病，发痒,红斑和鳞状斑块。从谦虚，局部斑块覆盖全身，牛皮癣的严重程度各不相同。牌匾,点滴,倒置,脓疱,和红皮病型银屑病是五种主要类型。大约90%的病例是斑块状银屑病，俗称寻常型银屑病。研究旨在确定rs2228570（FokI）变体和rs11568820（CDX2）变体对银屑病患者血清维生素D水平（SVD）的影响。以及两种变异与疾病严重程度之间的相关性。
方法：病例对照研究，包括95例寻常型银屑病患者和84例健康对照。临床调查，分子遗传学分析,并对两组进行生化分析。
结果：银屑病患者组SVD水平显著降低。FokI基因型分析,我们发现组间无显著差异.CDX2G/G基因型在患者中比对照更普遍。CDX2G/G基因型的中度寻常型银屑病患者SVD水平高于CDX2G/A,和CDX2A/Ap=0.003。
结论：研究发现患者和健康受试者的维生素D水平存在差异，以及不同FoKI和CDX2基因型的维生素D水平差异。
方法：病例对照研究，包括95例寻常型银屑病患者和84例健康对照。临床调查，分子遗传学分析,并对两组进行生化分析。
结果：银屑病患者组SVD水平显著降低。FokI基因型分析,我们发现组间无显著差异.CDX2G/G基因型在患者中比对照更普遍。CDX2G/G基因型的中度寻常型银屑病患者SVD水平高于CDX2G/A,和CDX2A/Ap=0.003。
结论：研究发现患者和健康受试者的维生素D水平存在差异，以及不同FoKI和CDX2基因型的维生素D水平差异。
