Abstract：
To date, treatment of Central Nervous System (CNS) pathology has largely focused on neuronal structure and function. Yet, revived attention towards fluid circulation within the CNS has exposed the need to further explore the role of glial cells in maintaining homeostasis within neural networks. In the past decade, discovery of the neural glymphatic network has revolutionized traditional understanding of fluid dynamics within the CNS. Advancements in neuroimaging have revealed alternative pathways of cerebrospinal fluid (CSF) generation and efflux. Here, we discuss emerging perspectives on the role of astrocytes in CSF hydrodynamics, with particular focus on the contribution of aquaporin-4 channels to the glymphatic network. Astrocytic structural features and expression patterns are detailed in relation to their function in maintaining integrity of the Blood Brain Barrier (BBB) as part of the neurovascular unit (NVU). This narrative also highlights the potential role of glial dysfunction in pathogenesis of neurodegenerative disease, hydrocephalus, intracranial hemorrhage, ischemic stroke, and traumatic brain injury. The purpose of this literature summary is to provide an update on the changing landscape of scientific theory surrounding production, flow, and absorption of cerebrospinal fluid. The overarching aim of this narrative review is to advance the conception of basic, translational, and clinical research endeavors investigating glia as therapeutic targets for neurological disease.
摘要：
迄今为止,中枢神经系统（CNS）病理的治疗主要集中在神经元的结构和功能。然而，对中枢神经系统内流体循环的重新关注暴露了进一步探索神经胶质细胞在维持神经网络内稳态中的作用的必要性。在过去的十年里,神经类淋巴网络的发现彻底改变了对CNS内流体动力学的传统理解。神经影像学的进步揭示了脑脊液（CSF）产生和流出的替代途径。这里,我们讨论了星形胶质细胞在CSF流体动力学中的作用的新观点，特别关注水通道蛋白-4通道对淋巴网络的贡献。星形细胞结构特征和表达模式详细说明了它们在维持作为神经血管单元（NVU）一部分的血脑屏障（BBB）完整性方面的功能。这种叙述还强调了神经胶质功能障碍在神经退行性疾病发病机制中的潜在作用。脑积水,颅内出血,缺血性卒中,和创伤性脑损伤。本文献摘要的目的是提供有关围绕生产的科学理论不断变化的最新信息，流量,和脑脊液的吸收。这篇叙事评论的总体目标是推进基本的概念，翻译,和临床研究努力研究神经胶质作为神经系统疾病的治疗靶标。
