Abstract：
BACKGROUND: The term \"vascular cognitive impairment\" (VCI) describes various cognitive conditions that include vascular elements. It increases the risk of morbidity and mortality in the elderly population and is the most common cognitive impairment associated with cerebrovascular disease. Understanding the etiology of VCI may aid in identifying approaches to target its possible therapy for the condition. Treatment of VCI has focused on vascular risk factors. There are no authorized conventional therapies available right now. The medications used to treat VCI are solely approved for symptomatic relief and are not intended to prevent or slow the development of VCI.
OBJECTIVE: The function of Chinese medicine in treating VCI has not yet been thoroughly examined. This review evaluates the preclinical and limited clinical evidence to comprehend the \"multi-component, multi-target, multi-pathway\" mechanism of Traditional Chinese medicine (TCM). It investigates the various multi-omics approaches in the search for the pathological mechanisms of VCI, as well as the new research strategies, in the hopes of supplying supportive evidence for the clinical treatment of VCI.
METHODS: This review used the Preferred Reporting Items for Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statements. Using integrated bioinformatics and network pharmacology approaches, a thorough evaluation and analysis of 25 preclinical studies published up to July 1, 2023, were conducted to shed light on the mechanisms of TCM for vascular cognitive impairment. The studies for the systematic review were located using the following databases: PubMed, Web of Science, Scopus, Cochrane, and ScienceDirect.
RESULTS: We discovered that the multi-omics analysis approach would hasten the discovery of the role of TCM in the treatment of VCI. It will explore components, compounds, targets, and pathways, slowing the progression of VCI from the perspective of inhibiting oxidative stress, stifling neuroinflammation, increasing cerebral blood flow, and inhibiting iron deposition by a variety of molecular mechanisms, which have significant implications for the treatment of VCI.
CONCLUSIONS: TCM is a valuable tool for developing dementia therapies, and further research is needed to determine how TCM components may affect the operation of the neurovascular unit. There are still some limitations, although several research have offered invaluable resources for searching for possible anti-dementia medicines and treatments. To gain new insights into the molecular mechanisms that precisely modulate the key molecules at different levels during pharmacological interventions-a prerequisite for comprehending the mechanism of action and determining the potential therapeutic value of the drugs-further research should employ more standardized experimental methods as well as more sophisticated science and technology. Given the results of this review, we advocate integrating chemical and biological component analysis approaches in future research on VCI to provide a more full and objective assessment of the standard of TCM. With the help of bioinformatics, a multi-omics analysis approach will hasten the discovery of the role of TCM in the treatment of VCI, which has significant implications for the treatment of VCI.
OBJECTIVE: The function of Chinese medicine in treating VCI has not yet been thoroughly examined. This review evaluates the preclinical and limited clinical evidence to comprehend the \"multi-component, multi-target, multi-pathway\" mechanism of Traditional Chinese medicine (TCM). It investigates the various multi-omics approaches in the search for the pathological mechanisms of VCI, as well as the new research strategies, in the hopes of supplying supportive evidence for the clinical treatment of VCI.
METHODS: This review used the Preferred Reporting Items for Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statements. Using integrated bioinformatics and network pharmacology approaches, a thorough evaluation and analysis of 25 preclinical studies published up to July 1, 2023, were conducted to shed light on the mechanisms of TCM for vascular cognitive impairment. The studies for the systematic review were located using the following databases: PubMed, Web of Science, Scopus, Cochrane, and ScienceDirect.
RESULTS: We discovered that the multi-omics analysis approach would hasten the discovery of the role of TCM in the treatment of VCI. It will explore components, compounds, targets, and pathways, slowing the progression of VCI from the perspective of inhibiting oxidative stress, stifling neuroinflammation, increasing cerebral blood flow, and inhibiting iron deposition by a variety of molecular mechanisms, which have significant implications for the treatment of VCI.
CONCLUSIONS: TCM is a valuable tool for developing dementia therapies, and further research is needed to determine how TCM components may affect the operation of the neurovascular unit. There are still some limitations, although several research have offered invaluable resources for searching for possible anti-dementia medicines and treatments. To gain new insights into the molecular mechanisms that precisely modulate the key molecules at different levels during pharmacological interventions-a prerequisite for comprehending the mechanism of action and determining the potential therapeutic value of the drugs-further research should employ more standardized experimental methods as well as more sophisticated science and technology. Given the results of this review, we advocate integrating chemical and biological component analysis approaches in future research on VCI to provide a more full and objective assessment of the standard of TCM. With the help of bioinformatics, a multi-omics analysis approach will hasten the discovery of the role of TCM in the treatment of VCI, which has significant implications for the treatment of VCI.
摘要：
背景：术语“血管性认知障碍”（VCI）描述了包括血管成分的各种认知状况。它增加了老年人群的发病率和死亡率的风险，是与脑血管疾病相关的最常见的认知障碍。了解VCI的病因可能有助于确定针对该疾病的可能治疗方法。VCI的治疗集中在血管危险因素上。目前尚无授权的常规疗法。用于治疗VCI的药物仅被批准用于缓解症状，并不旨在预防或减缓VCI的发展。
目的：中医药治疗VCI的作用尚未得到全面研究。这篇综述评估了临床前和有限的临床证据，以理解“多组分，多目标,多途径“中医机制”。它研究了寻找VCI病理机制的各种多组学方法，以及新的研究策略，希望为VCI的临床治疗提供支持性证据。
方法：本综述将“首选报告项目”用于系统综述和荟萃分析（PRISMA）报表。使用集成的生物信息学和网络药理学方法，我们对截至2023年7月1日发表的25项临床前研究进行了全面评估和分析,以阐明中医治疗血管性认知障碍的机制.系统评价的研究使用以下数据库进行定位：PubMed，WebofScience,Scopus,科克伦,和科学直接。
结果：我们发现，多组学分析方法将加速发现中医在VCI治疗中的作用。它将探索组件，化合物，目标,和路径，从抑制氧化应激的角度减缓VCI的进展，令人窒息的神经炎症，增加脑血流量，并通过多种分子机制抑制铁沉积，这对VCI的治疗有重要意义。
结论：中医是发展痴呆疗法的宝贵工具，需要进一步的研究来确定中药成分如何影响神经血管单元的操作。还有一些局限性,尽管几项研究为寻找可能的抗痴呆药物和治疗提供了宝贵的资源。为了获得对分子机制的新见解，这些机制可以在药理干预期间精确调节不同水平的关键分子-理解作用机制和确定药物潜在治疗价值的先决条件-进一步的研究应采用更标准化的实验方法以及更复杂的科学技术。鉴于本次审查的结果，我们主张在未来的VCI研究中整合化学和生物成分分析方法，以更全面和客观地评估中药的标准。在生物信息学的帮助下，多组学分析方法将加速发现中医在VCI治疗中的作用,这对VCI的治疗具有重要意义.
目的：中医药治疗VCI的作用尚未得到全面研究。这篇综述评估了临床前和有限的临床证据，以理解“多组分，多目标,多途径“中医机制”。它研究了寻找VCI病理机制的各种多组学方法，以及新的研究策略，希望为VCI的临床治疗提供支持性证据。
方法：本综述将“首选报告项目”用于系统综述和荟萃分析（PRISMA）报表。使用集成的生物信息学和网络药理学方法，我们对截至2023年7月1日发表的25项临床前研究进行了全面评估和分析,以阐明中医治疗血管性认知障碍的机制.系统评价的研究使用以下数据库进行定位：PubMed，WebofScience,Scopus,科克伦,和科学直接。
结果：我们发现，多组学分析方法将加速发现中医在VCI治疗中的作用。它将探索组件，化合物，目标,和路径，从抑制氧化应激的角度减缓VCI的进展，令人窒息的神经炎症，增加脑血流量，并通过多种分子机制抑制铁沉积，这对VCI的治疗有重要意义。
结论：中医是发展痴呆疗法的宝贵工具，需要进一步的研究来确定中药成分如何影响神经血管单元的操作。还有一些局限性,尽管几项研究为寻找可能的抗痴呆药物和治疗提供了宝贵的资源。为了获得对分子机制的新见解，这些机制可以在药理干预期间精确调节不同水平的关键分子-理解作用机制和确定药物潜在治疗价值的先决条件-进一步的研究应采用更标准化的实验方法以及更复杂的科学技术。鉴于本次审查的结果，我们主张在未来的VCI研究中整合化学和生物成分分析方法，以更全面和客观地评估中药的标准。在生物信息学的帮助下，多组学分析方法将加速发现中医在VCI治疗中的作用,这对VCI的治疗具有重要意义.
