PDF(Pubmed)
Abstract：
BACKGROUND Myasthenia gravis is a neuromuscular disorder that is strongly associated with thymoma. Although the presence of myasthenia gravis with other tumors is uncommon, approximately 50% of patients with thymoma have myasthenia gravis. Thymic Hodgkin lymphoma should be considered due to the multiple reported cases of patients with myasthenia gravis and Hodgkin lymphoma. In this report, we present the case of 24-year-old woman with myasthenia gravis who was incidentally found to have coexisting thymoma with thymic Hodgkin lymphoma. CASE REPORT A 24-year-old woman with a known case of vitiligo presented with a 2-year history of diplopia and incidental anterior mediastinal mass. Following investigations, myasthenia gravis was diagnosed and managed by pyridostigmine, prednisolone, and azathioprine. Regarding the anterior mediastinal mass, thymoma was suspected based on the presence of myasthenia gravis and radiological findings. She underwent extended transsternal thymectomy. The final histopathological report of the dissected thymus disclosed Hodgkin lymphoma pathology coexisting with thymoma. After the diagnosis of Hodgkin lymphoma nodular sclerosis type IIA was confirmed, 6 cycles of chemotherapy were administered. Four years of follow-up revealed no evidence of Hodgkin lymphoma. However, her symptoms of myasthenia gravis persisted despite Hodgkin lymphoma remission. CONCLUSIONS There is an unclear association between myasthenia gravies and Hodgkin lymphoma. Prior reports revealed regression of myasthenia gravies following Hodgkin lymphoma management, which suggests that myasthenia could be a complication of Hodgkin lymphoma. However, in our case, myasthenia gravis persisted after Hodgkin lymphoma management; therefore, further studies are needed to explore this association.
摘要：
背景技术重症肌无力是与胸腺瘤强烈相关的神经肌肉病症。尽管重症肌无力与其他肿瘤的存在并不常见，大约50%的胸腺瘤患者患有重症肌无力。由于重症肌无力和霍奇金淋巴瘤患者的多例报道，应考虑胸腺霍奇金淋巴瘤。在这份报告中,我们介绍了一例24岁的重症肌无力女性,偶然发现胸腺瘤合并胸腺霍奇金淋巴瘤.病例报告1例24岁女性，已知1例白癜风，有2年复视和偶发前纵隔肿块病史。经过调查,重症肌无力由吡啶斯的明诊断和治疗，泼尼松龙,还有硫唑嘌呤.关于前纵隔肿块，根据重症肌无力的存在和放射学检查结果怀疑胸腺瘤。她接受了扩大的经胸骨胸腺切除术。解剖胸腺的最终组织病理学报告显示，霍奇金淋巴瘤病理与胸腺瘤并存。确诊后的霍奇金淋巴瘤结节性硬化IIA型，化疗6个周期。四年的随访显示没有霍奇金淋巴瘤的证据。然而,尽管霍奇金淋巴瘤缓解,但重症肌无力症状持续.结论重症肌无力与霍奇金淋巴瘤之间的关系尚不清楚。先前的报告显示，霍奇金淋巴瘤治疗后，重症肌无力消退，这表明肌无力可能是霍奇金淋巴瘤的并发症。然而,在我们的案例中,重症肌无力在霍奇金淋巴瘤治疗后持续存在；因此，需要进一步的研究来探索这种关联.
