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Abstract：
Background and Objective: The aim of this retrospective cohort study is to evaluate the impact of assisted reproductive treatment (ART) on adverse maternal outcomes and the rate of hospitalization in maternal intensive care (MIC) in a tertiary university center in Liege, Belgium. Materials and Methods: This is a retrospective cohort study comparing two groups, 6557 patients who achieved pregnancy spontaneously and 330 patients who achieved pregnancy after ART, between January 2020 and December 2022. These patients were followed in the academic obstetrics department of Citadelle Hospital, Liège. The database of the ART center was compared with the database of the delivery unit to determine the cohort of patients who conceived after ART. Adverse maternal outcomes and MIC hospitalization rates were compared with between spontaneous pregnancies and ART groups. ART groups were also compared with each other. Results: The rate of hospitalization in maternal intensive care for patients who achieved pregnancy spontaneously was 12.1%, compared to 17.3% after ART. Comparing the rate of pre-eclampsia, 3.5% of spontaneous pregnancies were complicated by pre-eclampsia, while after ART, 10.9% of patients developed this complication during pregnancy. This rate was higher after IVF (12%) compared to intrauterine insemination and particularly after frozen embryo transfer (FET) in artificial cycle (17.9%). The birthweight of newborns after ART was also analyzed. A significant difference was obtained when comparing fresh embryo transfer with FET. Conclusions: Our study confirmed that FET in artificial cycle is a risk factor for pre-eclampsia and that fresh embryo transfer is associated with a higher rate of newborns with a lower percentile of birthweight. Our data showed that the rate of MIC hospitalization was significantly higher after ART but did not differ between groups.
摘要：
背景和目的：这项回顾性队列研究的目的是评估辅助生殖治疗（ART）对不良产妇结局的影响，以及在列日的第三级大学中心的产妇重症监护（MIC）住院率，比利时。材料和方法：这是一项回顾性队列研究，比较两组，6557例自发实现妊娠的患者和330例ART后实现妊娠的患者，2020年1月至2022年12月。这些患者在Citadelle医院的学术产科接受随访，列日.将ART中心的数据库与分娩单位的数据库进行比较，以确定ART后受孕的患者队列。比较了自然妊娠和ART组的不良产妇结局和MIC住院率。ART组也进行了相互比较。结果:在孕产妇重症监护中,自发性妊娠患者的住院率为12.1%,与ART后的17.3%相比。比较先兆子痫的发生率，3.5%的自发妊娠并发先兆子痫，在ART之后，10.9％的患者在怀孕期间发生了这种并发症。与宫腔内授精相比，IVF后的这一比率更高（12％），尤其是在人工周期的冷冻胚胎移植（FET）后（17.9％）。还分析了ART后新生儿的出生体重。当比较新鲜胚胎移植与FET时,获得显著差异。结论：我们的研究证实，人工周期中的FET是先兆子痫的危险因素，并且新鲜胚胎移植与较高的新生儿比率和较低的出生体重有关。我们的数据显示，ART后MIC住院率明显更高，但组间没有差异。
