PDF(Pubmed)
Abstract：
BACKGROUND: To date, no study has specifically examined children with acute-onset pupillary motility disorders (APMD). Especially in the Emergency Department (ED), it is crucial to distinguish benign and transient conditions from life-threatening or urgent conditions (UCs). The aim of the study is to describe the clinical characteristics of children with APMD and their association with an increased risk of UCs.
METHODS: We conducted a pediatric retrospective study of APMD referred to ED over a 10-year period. We described the characteristics in the overall sample and in two subgroups divided according to urgency of the underlying condition. Furthermore, we applied a logistic regression model to identify the variables predictive of LT condition.
RESULTS: We analyzed 101 patients. In 59.4%, the APMD was isolated. In patients with extra-ocular involvement, the most frequently associated features were altered consciousness, headache, and vomiting. Exposure to toxic agents was reported in 48.5%. Urgent conditions occurred significantly more frequently in older children, presenting bilateral APMD and/or other ocular or extra-ocular manifestations.
CONCLUSIONS: Our study shows that UCs most commonly occur in patients presenting with bilateral APMD and other associated features. In unilateral/isolated APMD ophthalmological examination, exclusion of toxic exposure and observation until resolution of symptoms should be recommended.
METHODS: We conducted a pediatric retrospective study of APMD referred to ED over a 10-year period. We described the characteristics in the overall sample and in two subgroups divided according to urgency of the underlying condition. Furthermore, we applied a logistic regression model to identify the variables predictive of LT condition.
RESULTS: We analyzed 101 patients. In 59.4%, the APMD was isolated. In patients with extra-ocular involvement, the most frequently associated features were altered consciousness, headache, and vomiting. Exposure to toxic agents was reported in 48.5%. Urgent conditions occurred significantly more frequently in older children, presenting bilateral APMD and/or other ocular or extra-ocular manifestations.
CONCLUSIONS: Our study shows that UCs most commonly occur in patients presenting with bilateral APMD and other associated features. In unilateral/isolated APMD ophthalmological examination, exclusion of toxic exposure and observation until resolution of symptoms should be recommended.
摘要：
背景：迄今为止，没有研究专门检查急性发作的瞳孔运动障碍(APMD)儿童.尤其是在急诊室（ED），区分良性和短暂性疾病与危及生命或紧急疾病（UC）至关重要。该研究的目的是描述APMD儿童的临床特征及其与UCs风险增加的关系。
方法：我们在10年的时间内对APMD进行了一项儿科回顾性研究。我们描述了整个样本和根据基本条件的紧迫性划分的两个子组的特征。此外，我们应用逻辑回归模型来确定LT条件的预测变量。
结果：我们分析了101例患者。59.4%,APMD被隔离。在眼外受累的患者中，最常见的相关特征是意识改变，头痛,和呕吐。据报道，接触有毒物质的比例为48.5%。紧急情况发生在年龄较大的儿童中明显更频繁，表现为双侧APMD和/或其他眼部或眼外表现。
结论：我们的研究表明，UCs最常见于表现为双侧APMD和其他相关特征的患者。在单侧/孤立性APMD眼科检查中，应建议排除毒性暴露并观察直至症状缓解。
方法：我们在10年的时间内对APMD进行了一项儿科回顾性研究。我们描述了整个样本和根据基本条件的紧迫性划分的两个子组的特征。此外，我们应用逻辑回归模型来确定LT条件的预测变量。
结果：我们分析了101例患者。59.4%,APMD被隔离。在眼外受累的患者中，最常见的相关特征是意识改变，头痛,和呕吐。据报道，接触有毒物质的比例为48.5%。紧急情况发生在年龄较大的儿童中明显更频繁，表现为双侧APMD和/或其他眼部或眼外表现。
结论：我们的研究表明，UCs最常见于表现为双侧APMD和其他相关特征的患者。在单侧/孤立性APMD眼科检查中，应建议排除毒性暴露并观察直至症状缓解。
