%0 Journal Article
%T Acute Pupillary Disorders in Children: A 10-Year Retrospective Study of 101 Patients.
%A Garone G
%A Roversi M
%A Pisani M
%A La Penna F
%A Musolino A
%A Cristaldi S
%A Musolino AM
%A Roberto A
%A Petrocelli G
%A Reale A
%A Midulla F
%A Villani A
%A Raucci U
%J Children (Basel)
%V 10
%N 11
%D 2023 Oct 26
%M 38002830
%F 2.835
%R 10.3390/children10111739
%X <B>BACKGROUND: </B>To date, no study has specifically examined children with acute-onset pupillary motility disorders (APMD). Especially in the Emergency Department (ED), it is crucial to distinguish benign and transient conditions from life-threatening or urgent conditions (UCs). The aim of the study is to describe the clinical characteristics of children with APMD and their association with an increased risk of UCs.<BR><B>METHODS: </B>We conducted a pediatric retrospective study of APMD referred to ED over a 10-year period. We described the characteristics in the overall sample and in two subgroups divided according to urgency of the underlying condition. Furthermore, we applied a logistic regression model to identify the variables predictive of LT condition.<BR><B>RESULTS: </B>We analyzed 101 patients. In 59.4%, the APMD was isolated. In patients with extra-ocular involvement, the most frequently associated features were altered consciousness, headache, and vomiting. Exposure to toxic agents was reported in 48.5%. Urgent conditions occurred significantly more frequently in older children, presenting bilateral APMD and/or other ocular or extra-ocular manifestations.<BR><B>CONCLUSIONS: </B>Our study shows that UCs most commonly occur in patients presenting with bilateral APMD and other associated features. In unilateral/isolated APMD ophthalmological examination, exclusion of toxic exposure and observation until resolution of symptoms should be recommended.