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Abstract：
OBJECTIVE: The aim of this study concerns the evaluation of peripapillary vessel indices in childhood glaucoma (CG) and healthy subjects.
METHODS: In this prospective, unicenter, observational cross-sectional study, patients with CG and age and sex-matched healthy subjects were included. We compared retinal nerve fiber layer (RNFL) measurements in optical coherence tomography (OCT), peripapillary vessel density (PVD), and the flux index (FI) of the superficial vascular plexus from OCT angiography (OCT-A) between CG patients and control groups.
RESULTS: We included 39 patients (68 eyes) with CG and 50 (95 eyes) healthy subjects. The peripapillary RNFL thickness, vessel density, and flux index were significantly lower in the CG group than in the control group. The mean PVD of CG patients was 0.52 ± 0.043%, compared with 0.55 ± 0.014%, p < 0.0001 in healthy subjects. The mean FI was 0.32 ± 0.054 versus 0.37 ± 0.028, p < 0.0001, in CG patients and healthy subjects, respectively. PVD and FI in the superior, inferior, and temporal sectors were significantly lower in CG. The peripapillary RNFL thickness showed a higher area under the ROC curve (AUROC) for discriminating healthy and CG eyes and was significantly different than the PVD (0.797, 95%CI 0.726-0.869; p < 0.0001 vs. 0.664, 95%CI 0.574-0.752; p 0.00037), p 0.012.
CONCLUSIONS: PVD and FI show lower values in CG and correlate with RNFL thickness measurement but have lower diagnostic ability than RNFL thickness measurement. Our results reveal possible differences in the pathogenesis of microvascular compromise in childhood glaucoma patients.
METHODS: In this prospective, unicenter, observational cross-sectional study, patients with CG and age and sex-matched healthy subjects were included. We compared retinal nerve fiber layer (RNFL) measurements in optical coherence tomography (OCT), peripapillary vessel density (PVD), and the flux index (FI) of the superficial vascular plexus from OCT angiography (OCT-A) between CG patients and control groups.
RESULTS: We included 39 patients (68 eyes) with CG and 50 (95 eyes) healthy subjects. The peripapillary RNFL thickness, vessel density, and flux index were significantly lower in the CG group than in the control group. The mean PVD of CG patients was 0.52 ± 0.043%, compared with 0.55 ± 0.014%, p < 0.0001 in healthy subjects. The mean FI was 0.32 ± 0.054 versus 0.37 ± 0.028, p < 0.0001, in CG patients and healthy subjects, respectively. PVD and FI in the superior, inferior, and temporal sectors were significantly lower in CG. The peripapillary RNFL thickness showed a higher area under the ROC curve (AUROC) for discriminating healthy and CG eyes and was significantly different than the PVD (0.797, 95%CI 0.726-0.869; p < 0.0001 vs. 0.664, 95%CI 0.574-0.752; p 0.00037), p 0.012.
CONCLUSIONS: PVD and FI show lower values in CG and correlate with RNFL thickness measurement but have lower diagnostic ability than RNFL thickness measurement. Our results reveal possible differences in the pathogenesis of microvascular compromise in childhood glaucoma patients.
摘要：
目的：本研究的目的是评估儿童青光眼（CG）和健康受试者的乳头周围血管指数。
方法：在此前瞻性中，Unicenter,观察性横断面研究，纳入了CG患者以及年龄和性别匹配的健康受试者.我们比较了光学相干断层扫描（OCT）中的视网膜神经纤维层（RNFL）测量，乳头周围血管密度（PVD），CG患者和对照组之间的OCT血管造影（OCT-A）的浅表血管丛通量指数（FI）。
结果：我们包括39例（68只眼）CG患者和50例（95只眼）健康受试者。乳头周围RNFL厚度，血管密度,CG组的通量指数明显低于对照组。CG患者的平均PVD为0.52±0.043%，与0.55±0.014%相比，在健康受试者中p<0.0001。CG患者和健康受试者的平均FI为0.32±0.054和0.37±0.028，p<0.0001，分别。PVD和FI在上级，劣等,CG和时间部门明显较低。乳头周围RNFL厚度显示出更高的ROC曲线下面积（AUROC），可区分健康眼和CG眼，并且与PVD显着不同（0.797，95CI0.726-0.869；p<0.0001vs.0.664，95CI0.574-0.752；p0.00037），第0.012页。
结论：PVD和FI在CG中显示出较低的值，并且与RNFL厚度测量相关，但诊断能力低于RNFL厚度测量。我们的结果揭示了儿童青光眼患者微血管损害的发病机理可能存在差异。
方法：在此前瞻性中，Unicenter,观察性横断面研究，纳入了CG患者以及年龄和性别匹配的健康受试者.我们比较了光学相干断层扫描（OCT）中的视网膜神经纤维层（RNFL）测量，乳头周围血管密度（PVD），CG患者和对照组之间的OCT血管造影（OCT-A）的浅表血管丛通量指数（FI）。
结果：我们包括39例（68只眼）CG患者和50例（95只眼）健康受试者。乳头周围RNFL厚度，血管密度,CG组的通量指数明显低于对照组。CG患者的平均PVD为0.52±0.043%，与0.55±0.014%相比，在健康受试者中p<0.0001。CG患者和健康受试者的平均FI为0.32±0.054和0.37±0.028，p<0.0001，分别。PVD和FI在上级，劣等,CG和时间部门明显较低。乳头周围RNFL厚度显示出更高的ROC曲线下面积（AUROC），可区分健康眼和CG眼，并且与PVD显着不同（0.797，95CI0.726-0.869；p<0.0001vs.0.664，95CI0.574-0.752；p0.00037），第0.012页。
结论：PVD和FI在CG中显示出较低的值，并且与RNFL厚度测量相关，但诊断能力低于RNFL厚度测量。我们的结果揭示了儿童青光眼患者微血管损害的发病机理可能存在差异。
