Abstract：
OBJECTIVE: To explore the role of choroidopathy in diabetic retinopathy (DR) by investigating the correlation between alterations of choroidal vessel and photoreceptors during the early stage of DR.
METHODS: We performed a cross-sectional comparison of diabetic patients without DR (NDR group; n=16) and those with mild nonproliferative diabetic retinopathy (NPDR group; n=39). Optical coherence tomography (OCT) images of choroidal vessel alterations and photoreceptor structures were evaluated using the choroidal vascularity index (CVI) and adjusted ellipsoid zone (EZ) reflectivity, respectively. To evaluate the function of cone photoreceptors, the fundamental, harmonic amplitudes, the parameters S and Rmp3 were calculated from the electroretinogram (ERG). These factors were compared between groups. The correlation between the CVI and parameters describing the function and structure of the photoreceptors was evaluated.
RESULTS: The significant decrease was observed in the CVI in the NPDR group compared to the NDR group (0.67 ± 0.04 vs. 0.70 ± 0.06; p = 0.028), but not in the adjusted EZ reflectivity or ERG parameters. In NPDR group and merging the 2 groups, CVI was moderately positively correlated with the fundamental amplitude obtained by the flicker ERG (NPDR only: r = 0.506; p = 0.001; merge the 2 groups: r = 0.423; p = 0.001), which was regulated by the response of the cone photoreceptors. The CVI was positively and moderately correlated with the logS (NPDR only: r = 0.462; p = 0.003; merge the 2 groups: r = 0.355; p = 0.008), indicating the sensitivity of cone cell light transduction.
CONCLUSIONS: Compared to eyes without DR, CVI decreased representing choroidal vascular changes in eyes with mild NPDR. These changes may be related to the functional impairment of cone photoreceptors, especially phototransduction sensitivity, as the DR develops.
METHODS: We performed a cross-sectional comparison of diabetic patients without DR (NDR group; n=16) and those with mild nonproliferative diabetic retinopathy (NPDR group; n=39). Optical coherence tomography (OCT) images of choroidal vessel alterations and photoreceptor structures were evaluated using the choroidal vascularity index (CVI) and adjusted ellipsoid zone (EZ) reflectivity, respectively. To evaluate the function of cone photoreceptors, the fundamental, harmonic amplitudes, the parameters S and Rmp3 were calculated from the electroretinogram (ERG). These factors were compared between groups. The correlation between the CVI and parameters describing the function and structure of the photoreceptors was evaluated.
RESULTS: The significant decrease was observed in the CVI in the NPDR group compared to the NDR group (0.67 ± 0.04 vs. 0.70 ± 0.06; p = 0.028), but not in the adjusted EZ reflectivity or ERG parameters. In NPDR group and merging the 2 groups, CVI was moderately positively correlated with the fundamental amplitude obtained by the flicker ERG (NPDR only: r = 0.506; p = 0.001; merge the 2 groups: r = 0.423; p = 0.001), which was regulated by the response of the cone photoreceptors. The CVI was positively and moderately correlated with the logS (NPDR only: r = 0.462; p = 0.003; merge the 2 groups: r = 0.355; p = 0.008), indicating the sensitivity of cone cell light transduction.
CONCLUSIONS: Compared to eyes without DR, CVI decreased representing choroidal vascular changes in eyes with mild NPDR. These changes may be related to the functional impairment of cone photoreceptors, especially phototransduction sensitivity, as the DR develops.
摘要：
目的：通过研究脉络膜血管改变与糖尿病视网膜病变（DR）早期光感受器的相关性，探讨脉络膜病变在DR中的作用。
方法：我们对无DR的糖尿病患者（NDR组，n=16）和轻度非增生性糖尿病视网膜病变患者（NPDR组，n=39）进行了横断面比较。使用脉络膜血管分布指数（CVI）和调整后的椭球区（EZ）反射率评估脉络膜血管改变和光感受器结构的光学相干断层扫描（OCT）图像。分别。为了评估视锥光感受器的功能，最基本的,谐波振幅，根据视网膜电图(ERG)计算参数S和Rmp3.组间比较这些因素。评估了CVI与描述光感受器功能和结构的参数之间的相关性。
结果：与NDR组相比，NPDR组的CVI显着下降（0.67±0.04vs.0.70±0.06；p=0.028），但不在调整后的EZ反射率或ERG参数中。在NPDR组中，合并2组，CVI与闪烁ERG获得的基波振幅呈中度正相关（仅NPDR：r=0.506；p=0.001；合并2组：r=0.423；p=0.001），这是由视锥细胞的反应调节的。CVI与logS呈正相关(仅NPDR:r=0.462;p=0.003;合并2组:r=0.355;p=0.008),表明视锥细胞光转导的敏感性。
结论：与没有DR的眼睛相比，CVI降低，代表轻度NPDR眼睛的脉络膜血管变化。这些变化可能与视锥细胞的功能受损有关，特别是光传导敏感性，随着DR的发展。
方法：我们对无DR的糖尿病患者（NDR组，n=16）和轻度非增生性糖尿病视网膜病变患者（NPDR组，n=39）进行了横断面比较。使用脉络膜血管分布指数（CVI）和调整后的椭球区（EZ）反射率评估脉络膜血管改变和光感受器结构的光学相干断层扫描（OCT）图像。分别。为了评估视锥光感受器的功能，最基本的,谐波振幅，根据视网膜电图(ERG)计算参数S和Rmp3.组间比较这些因素。评估了CVI与描述光感受器功能和结构的参数之间的相关性。
结果：与NDR组相比，NPDR组的CVI显着下降（0.67±0.04vs.0.70±0.06；p=0.028），但不在调整后的EZ反射率或ERG参数中。在NPDR组中，合并2组，CVI与闪烁ERG获得的基波振幅呈中度正相关（仅NPDR：r=0.506；p=0.001；合并2组：r=0.423；p=0.001），这是由视锥细胞的反应调节的。CVI与logS呈正相关(仅NPDR:r=0.462;p=0.003;合并2组:r=0.355;p=0.008),表明视锥细胞光转导的敏感性。
结论：与没有DR的眼睛相比，CVI降低，代表轻度NPDR眼睛的脉络膜血管变化。这些变化可能与视锥细胞的功能受损有关，特别是光传导敏感性，随着DR的发展。
