PDF(Pubmed)
Abstract：
The Robin sequence is a congenital anomaly characterized by a triad of features: micrognathia, glossoptosis, and airway obstruction. This comprehensive historical review maps the evolution of approaches and appliances for its treatment from the past to the current modern possibilities of an interdisciplinary combination of modern engineering, medicine, materials, and computer science combined approach with emphasis on designing appliances inspired by nature and individual human anatomy. Current biomimetic designs are clinically applied, resulting in appliances that are more efficient, comfortable, sustainable, and safer than legacy traditional designs. This review maps the treatment modalities that have been used for patients with a Robin sequence over the years. Early management of the Robin sequence focused primarily on airway maintenance and feeding support, while current management strategies involve both nonsurgical and surgical interventions and biomimetic biocompatible personalized appliances. The goal of this paper was to provide a review of the evolution of management strategies for patients with the Robin sequence that led to the current interdisciplinary biomimetic approaches impacting the future of Robin Sequence treatment with biomimetics at the forefront.
摘要：
Robin序列是一种先天性异常，其特征是具有以下特征的三元组：微下颌，舌下垂，和气道阻塞。这个全面的历史回顾绘制了方法和设备的演变，从过去到现代工程的跨学科组合的现代可能性，医学,材料,和计算机科学相结合的方法，重点是设计受自然和个体人体解剖学启发的电器。目前的仿生设计在临床应用，导致更高效的电器，舒适,可持续,比传统设计更安全。这篇综述绘制了多年来用于Robin序列患者的治疗方式。罗宾序列的早期管理主要集中在气道维持和喂养支持，而当前的管理策略涉及非手术和手术干预以及仿生生物相容性个性化矫治器。本文的目的是对Robin序列患者的管理策略的演变进行综述，这些策略导致当前的跨学科仿生方法影响了Robin序列治疗的未来，而仿生药物处于最前沿。
