Abstract：
BACKGROUND: The early diagnosis of acral lentiginous melanoma (ALM) contributes to clinical outcomes since ALM can be mistaken for acral melanocytic nevus (AMN). ALM occurrence is reported to correlate with stress-bearing areas, which may assist in differential diagnoses. Our objective is to evaluate the distribution patterns of ALMs and AMNs on the palms and soles among Taiwanese patients.
METHODS: A retrospective analysis was performed by reviewing the charts of 1400 patients diagnosed with benign and malignant pigmented lesions confirmed after excisional biopsy at our institution between 2000 and 2022 in Taiwan. Correlations between lesions and clinicopathological factors were analyzed.
RESULTS: 309 AMNs and 177 ALMs were included. Mechanical stress was significantly associated with plantar ALMs (weight-bearing area: 92.65 %, arch: 7.35 %, P < 0.001). Significant differences in the distribution patterns were observed for plantar ALMs compared with all AMNs (P < 0.001) and non-atypical AMNs (P < 0.001), but were not observed between palmar AMNs and ALMs.
CONCLUSIONS: Plantar ALMs were most commonly observed on the weight-bearing areas of the soles, distinct from the distribution of all AMNs and of non-atypical AMNs. The distribution features and anatomic mapping of ALMs may facilitate the early clinical diagnosis of ALM.
METHODS: A retrospective analysis was performed by reviewing the charts of 1400 patients diagnosed with benign and malignant pigmented lesions confirmed after excisional biopsy at our institution between 2000 and 2022 in Taiwan. Correlations between lesions and clinicopathological factors were analyzed.
RESULTS: 309 AMNs and 177 ALMs were included. Mechanical stress was significantly associated with plantar ALMs (weight-bearing area: 92.65 %, arch: 7.35 %, P < 0.001). Significant differences in the distribution patterns were observed for plantar ALMs compared with all AMNs (P < 0.001) and non-atypical AMNs (P < 0.001), but were not observed between palmar AMNs and ALMs.
CONCLUSIONS: Plantar ALMs were most commonly observed on the weight-bearing areas of the soles, distinct from the distribution of all AMNs and of non-atypical AMNs. The distribution features and anatomic mapping of ALMs may facilitate the early clinical diagnosis of ALM.
摘要：
背景：由于ALM可能被误认为是肢端黑素细胞痣（AMN），因此早期诊断肢端浅色黑色素瘤（ALM）有助于临床结果。据报道，ALM的发生与应力承受区域相关，这可能有助于鉴别诊断。我们的目的是评估台湾患者手掌和足底ALM和AMN的分布模式。
方法：回顾性分析了2000年至2022年在台湾我院经活检证实的1400例良性和恶性色素性病变患者的图表。分析病变与临床病理因素的相关性。
结果：包括309个AMN和177个ALM。机械应力与足底ALMs显着相关（负重面积：92.65％，拱顶：7.35%，P<0.001)。与所有AMN（P<0.001）和非非典型AMN（P<0.001）相比，足底ALM的分布模式存在显着差异，
结论：足底ALM最常见于鞋底的负重区域，与所有AMN和非非典型AMN的分布不同。ALM的分布特征和解剖作图可能有助于ALM的早期临床诊断。
方法：回顾性分析了2000年至2022年在台湾我院经活检证实的1400例良性和恶性色素性病变患者的图表。分析病变与临床病理因素的相关性。
结果：包括309个AMN和177个ALM。机械应力与足底ALMs显着相关（负重面积：92.65％，拱顶：7.35%，P<0.001)。与所有AMN（P<0.001）和非非典型AMN（P<0.001）相比，足底ALM的分布模式存在显着差异，
结论：足底ALM最常见于鞋底的负重区域，与所有AMN和非非典型AMN的分布不同。ALM的分布特征和解剖作图可能有助于ALM的早期临床诊断。
