Abstract：
UNASSIGNED: The global COVID-19 outbreak, started in December 2019, resulted in severe financial losses and extraordinary health crises. Finding a potent and secure medication candidate to treat SARS-CoV-2 infection and its symptoms is still an urgent global need. After reviewing previous studies, olive leaves, being rich in polyphenolic compounds (a large class of bioactive substances naturally found in plants), were proposed as a viable co-therapy supplement to treat and improve clinical symptoms in COVID-19 patients. It has long been known that olive tree polyphenols-such as oleuropein, hydroxytyrosol, verbascoside, as well as triterpenoids like maslinic, ursolic, and oleanolic acids-have anti-inflammatory and multitarget antiviral effects on several virus families, and they could be one of the reasons of the beneficial effects of the Mediterranean diet against COVID-19. Thus, olive tree poly-phenols were tested in silico and in vitro for preventing SARS-CoV-2 infection, claiming that they have beneficial effects. Nevertheless, there is still a small number of research studies on this topic. The aim of this scoping review is to provide more information and offer an opinion on the feasibility of using olive tree polyphenols as a springboard for the creation of innovative natural remedies against this viral illness, ultimately planning future relevant studies.
摘要：
■全球COVID-19爆发，始于2019年12月，导致严重的财务损失和非同寻常的健康危机。寻找有效且安全的候选药物来治疗SARS-CoV-2感染及其症状仍然是全球迫切需要。在回顾了以前的研究之后，橄榄叶,富含多酚化合物（植物中天然存在的一大类生物活性物质），被提议作为一种可行的联合治疗补充剂来治疗和改善COVID-19患者的临床症状。人们早就知道，橄榄树多酚-如橄榄苦苷，羟基酪醇，Verbascoside,以及三萜类化合物，如maslinic，熊,齐墩果酸对几个病毒家族有抗炎和多靶点抗病毒作用，它们可能是地中海饮食对COVID-19有益影响的原因之一。因此，橄榄树多酚在电脑和体外测试，以防止SARS-CoV-2感染，声称它们有有益的效果。然而，关于这一主题的研究仍然很少。这项范围审查的目的是提供更多信息，并就使用橄榄树多酚作为创建针对这种病毒性疾病的创新自然疗法的跳板的可行性提供意见。最终规划未来的相关研究。
