Abstract：
BACKGROUND: Tobacco smoking has been described as the main cause of chronic obstructive pulmonary disease (COPD) and this habit is clearly more frequent among individuals with psychosis than in the general population, with rates reaching up to 60%. However, little attention has been focused on the association of COPD and psychosis. We aimed to explore the risk of presenting early lung function alterations in a group of individuals with psychosis.
METHODS: Following an observational cross-sectional design we studied a cohort of individuals with established psychosis (N=128), and compared them with a sex, age, and smoking habit matched control group (N=79). We evaluated respiratory symptoms by means of mMRC, CAT and Dyspnea-12 scales. And lung function through spirometry tests.
RESULTS: Individuals with psychosis presented more respiratory symptoms than controls. Similarly, we observed significant differences in the lung function tests between these two groups, where individuals with psychosis presented worse results in most of the spirometry mean values (FEV1 or forced expiratory volume in the first one second: 3.29L vs. 3.75L, p<0.001; forced vital capacity or FVC: 4.25L vs. 4.72L, p=0.002; and FEV1/FVC ratio: 0.78 vs. 0.80, p=0.052). Patients also presented worse values of lung diffusion, with lower diffusing capacity for carbon monoxide (DLCO) than controls (6.95 vs. 8.54mmol/min/kPa, p<0.001).
CONCLUSIONS: The individuals with psychosis in our study presented greater respiratory symptoms and poorer lung function measured through spirometry. These signs have been described as early signs of COPD.
METHODS: Following an observational cross-sectional design we studied a cohort of individuals with established psychosis (N=128), and compared them with a sex, age, and smoking habit matched control group (N=79). We evaluated respiratory symptoms by means of mMRC, CAT and Dyspnea-12 scales. And lung function through spirometry tests.
RESULTS: Individuals with psychosis presented more respiratory symptoms than controls. Similarly, we observed significant differences in the lung function tests between these two groups, where individuals with psychosis presented worse results in most of the spirometry mean values (FEV1 or forced expiratory volume in the first one second: 3.29L vs. 3.75L, p<0.001; forced vital capacity or FVC: 4.25L vs. 4.72L, p=0.002; and FEV1/FVC ratio: 0.78 vs. 0.80, p=0.052). Patients also presented worse values of lung diffusion, with lower diffusing capacity for carbon monoxide (DLCO) than controls (6.95 vs. 8.54mmol/min/kPa, p<0.001).
CONCLUSIONS: The individuals with psychosis in our study presented greater respiratory symptoms and poorer lung function measured through spirometry. These signs have been described as early signs of COPD.
摘要：
背景：吸烟已被描述为慢性阻塞性肺疾病（COPD）的主要原因，这种习惯在精神病患者中比在普通人群中更常见，率高达60%。然而,人们很少关注COPD和精神病的关联.我们旨在探讨一组精神病患者出现早期肺功能改变的风险。
方法：在观察性横断面设计之后，我们研究了一组精神病患者（N=128），并将它们与性爱进行比较，年龄,吸烟习惯与对照组相匹配(N=79)。我们通过mMRC评估呼吸道症状，CAT和呼吸困难-12量表。通过肺活量测试和肺功能。
结果：精神病患者的呼吸道症状比对照组多，.同样，我们观察到两组之间的肺功能测试存在显着差异，其中精神病患者在大多数肺活量测定平均值中表现出较差的结果（前一秒的FEV1或用力呼气量：3.29Lvs3.75L，p<0.001；用力肺活量或FVC：4.25Lvs4.72L，p=0.002；FEV1/FVC比率：0.78vs0.80，p=0.052）。患者的肺弥散值也较差，一氧化碳扩散能力(DLCO)低于对照组(6.95vs.8.54mmol/min/kP,p<0.001)。
结论：在我们的研究中，通过肺活量测定，精神病患者表现出更大的呼吸道症状和更差的肺功能。这些体征已被描述为COPD的早期体征。
方法：在观察性横断面设计之后，我们研究了一组精神病患者（N=128），并将它们与性爱进行比较，年龄,吸烟习惯与对照组相匹配(N=79)。我们通过mMRC评估呼吸道症状，CAT和呼吸困难-12量表。通过肺活量测试和肺功能。
结果：精神病患者的呼吸道症状比对照组多，.同样，我们观察到两组之间的肺功能测试存在显着差异，其中精神病患者在大多数肺活量测定平均值中表现出较差的结果（前一秒的FEV1或用力呼气量：3.29Lvs3.75L，p<0.001；用力肺活量或FVC：4.25Lvs4.72L，p=0.002；FEV1/FVC比率：0.78vs0.80，p=0.052）。患者的肺弥散值也较差，一氧化碳扩散能力(DLCO)低于对照组(6.95vs.8.54mmol/min/kP,p<0.001)。
结论：在我们的研究中，通过肺活量测定，精神病患者表现出更大的呼吸道症状和更差的肺功能。这些体征已被描述为COPD的早期体征。
