PDF(Pubmed)
Abstract：
The desire to create biomolecules modified with functionalities that go beyond nature\'s toolbox has resulted in the development of biocompatible and selective methodologies and reagents, each with different scope and limitations. In this overview, we highlight recent advances in the field of bioconjugation from 2016 to 2023. First, (metal-mediated) protein functionalization by exploiting the specific reactivity of amino acids will be discussed, followed by novel bioorthogonal reagents for bioconjugation of modified biomolecules.
摘要：
希望创造出具有超越自然工具箱的功能修饰的生物分子，这导致了生物相容性和选择性方法和试剂的发展。每个都有不同的范围和限制。在本概述中,我们重点介绍了2016年至2023年生物缀合领域的最新进展。首先,将讨论通过利用氨基酸的特定反应性进行（金属介导的）蛋白质官能化，随后是用于修饰的生物分子的生物缀合的新型生物正交试剂。
