%0 Journal Article
%T Recent Advances in Bioorthogonal Ligation and Bioconjugation.
%A Zielke FM
%A Rutjes FPJT
%J Top Curr Chem (Cham)
%V 381
%N 6
%D 2023 Nov 22
%M 37991570
%F 8.905
%R 10.1007/s41061-023-00445-6
%X The desire to create biomolecules modified with functionalities that go beyond nature's toolbox has resulted in the development of biocompatible and selective methodologies and reagents, each with different scope and limitations. In this overview, we highlight recent advances in the field of bioconjugation from 2016 to 2023. First, (metal-mediated) protein functionalization by exploiting the specific reactivity of amino acids will be discussed, followed by novel bioorthogonal reagents for bioconjugation of modified biomolecules.