Abstract：
Although diuretics play an important role in triple-whammy acute kidney injury (AKI), it is unclear whether the type of diuretic influences the risk of triple-whammy AKI. The aim of this study was to evaluate whether vasopressin receptor antagonists affect triple-whammy AKI. This cross-sectional study used disproportionality analysis of VigiBase data to assess the risk of AKI with various diuretics. Although multiple logistic regression analysis showed that aldosterone antagonists (odds ratio [OR] 2.19, 95% CI 2.01-2.37), loop diuretics (OR 4.40, 95% CI 4.07-4.76) and thiazide diuretics (OR 1.98, 95% CI 1.83-2.15) increased the risk of AKI in patients who received non-steroidal anti-inflammatory drugs (NSAIDs) and renin-angiotensin system inhibitors (RASi), vasopressin receptor antagonists did not increase the risk of AKI in those patients. Vasopressin receptor antagonists might not influence the development of triple-whammy AKI.
摘要：
尽管利尿剂在三重打击急性肾损伤（AKI）中起重要作用，目前尚不清楚利尿剂的类型是否影响三重打击AKI的风险.这项研究的目的是评估加压素受体拮抗剂是否会影响三重打击的AKI。这项横断面研究使用VigiBase数据的不相称性分析来评估各种利尿剂的AKI风险。尽管多元logistic回归分析显示醛固酮拮抗剂(比值比[OR]2.19,95%CI2.01-2.37),loop利尿剂（OR4.40，95%CI4.07-4.76），和噻嗪类利尿剂（OR1.98，95％CI1.83-2.15）增加了接受非甾体抗炎药（NSAIDs）和肾素-血管紧张素系统抑制剂（RASi）的患者发生AKI的风险，加压素受体拮抗剂并未增加这些患者的AKI风险.血管加压素受体拮抗剂可能不会影响三重打击AKI的发展。
