%0 Journal Article
%T Influence of vasopressin receptor antagonists on triple-whammy acute kidney injury: A VigiBase analysis.
%A Mitsuboshi S
%A Hayakawa K
%A Hamano H
%A Oshima A
%A Takeda T
%A Murakawa K
%A Mori H
%A Zamami Y
%J Br J Clin Pharmacol
%V 90
%N 3
%D 2024 03 21
%M 37990649
%F 3.716
%R 10.1111/bcp.15974
%X Although diuretics play an important role in triple-whammy acute kidney injury (AKI), it is unclear whether the type of diuretic influences the risk of triple-whammy AKI. The aim of this study was to evaluate whether vasopressin receptor antagonists affect triple-whammy AKI. This cross-sectional study used disproportionality analysis of VigiBase data to assess the risk of AKI with various diuretics. Although multiple logistic regression analysis showed that aldosterone antagonists (odds ratio [OR] 2.19, 95% CI 2.01-2.37), loop diuretics (OR 4.40, 95% CI 4.07-4.76) and thiazide diuretics (OR 1.98, 95% CI 1.83-2.15) increased the risk of AKI in patients who received non-steroidal anti-inflammatory drugs (NSAIDs) and renin-angiotensin system inhibitors (RASi), vasopressin receptor antagonists did not increase the risk of AKI in those patients. Vasopressin receptor antagonists might not influence the development of triple-whammy AKI.