Abstract：
BACKGROUND: Nitric oxide (NO) may be related to the pathogenesis of several morbidities in extremely preterm infants, including late-onset adrenal insufficiency. However, eosinophilia is observed under pathological conditions with adrenal insufficiency. Therefore, this study explored postnatal changes in NO levels and eosinophil counts in extremely preterm infants with and without morbidities.
METHODS: Nineteen extremely preterm infants with a median gestational age of 27.0 weeks and median birth weight of 888 g were enrolled in this study. Serum levels of nitrogen oxides (NOx) and peripheral blood eosinophil counts were measured at birth and every 2 weeks thereafter. Morbidities of the study group were diagnosed using a single criterion.
RESULTS: Serum NOx levels (mean ± standard deviation) were 22.5 ± 14.9 μmol/L, 51.2 ± 23.7 μmol/L, 42.4 ± 15.2 μmol/L, and 33.8 ± 9.4 μmol/L at birth and 2, 4, and 6 weeks of age, respectively. The serum NOx level at 2 weeks of age was significantly higher than that at birth and 6 weeks of age. Eosinophil counts, which increase with adrenal insufficiency, were measured simultaneously and were 145 ± 199/μL, 613 ± 625/μL, 466 ± 375/μL, and 292 ± 228/μL at birth and 2, 4, and 6 weeks of age, respectively. These values showed that the eosinophil count was significantly higher at 2 weeks of age than at birth and 6 weeks of age. The serum NOx level of infants without chorioamnionitis was significantly increased at 4 weeks of age, and the eosinophil count of infants with necrotizing enterocolitis was significantly increased at 2 weeks of age. No correlation with the NOx level or eosinophil count was observed in infants with late-onset circulatory collapse.
CONCLUSIONS: The postnatal serum NOx level and eosinophil count were significantly correlated with each other and peaked at 2 weeks of age.
METHODS: Nineteen extremely preterm infants with a median gestational age of 27.0 weeks and median birth weight of 888 g were enrolled in this study. Serum levels of nitrogen oxides (NOx) and peripheral blood eosinophil counts were measured at birth and every 2 weeks thereafter. Morbidities of the study group were diagnosed using a single criterion.
RESULTS: Serum NOx levels (mean ± standard deviation) were 22.5 ± 14.9 μmol/L, 51.2 ± 23.7 μmol/L, 42.4 ± 15.2 μmol/L, and 33.8 ± 9.4 μmol/L at birth and 2, 4, and 6 weeks of age, respectively. The serum NOx level at 2 weeks of age was significantly higher than that at birth and 6 weeks of age. Eosinophil counts, which increase with adrenal insufficiency, were measured simultaneously and were 145 ± 199/μL, 613 ± 625/μL, 466 ± 375/μL, and 292 ± 228/μL at birth and 2, 4, and 6 weeks of age, respectively. These values showed that the eosinophil count was significantly higher at 2 weeks of age than at birth and 6 weeks of age. The serum NOx level of infants without chorioamnionitis was significantly increased at 4 weeks of age, and the eosinophil count of infants with necrotizing enterocolitis was significantly increased at 2 weeks of age. No correlation with the NOx level or eosinophil count was observed in infants with late-onset circulatory collapse.
CONCLUSIONS: The postnatal serum NOx level and eosinophil count were significantly correlated with each other and peaked at 2 weeks of age.
摘要：
背景：一氧化氮（NO）可能与极早产儿的几种发病率有关，包括迟发性肾上腺功能不全.然而,在肾上腺功能不全的病理条件下观察到嗜酸性粒细胞增多。因此,这项研究探讨了有或无发病率的极早产儿的出生后NO水平和嗜酸性粒细胞计数的变化.
方法：本研究纳入了19例中位胎龄为27.0周、中位出生体重为888g的极早产儿。出生时和此后每2周测量血清氮氧化物（NOx）水平和外周血嗜酸性粒细胞计数。使用单一标准诊断研究组的发病率。
结果：血清NOx水平（平均值±标准偏差）为22.5±14.9μmol/L，51.2±23.7μmol/L,42.4±15.2μmol/L,出生时和2、4和6周龄时33.8±9.4μmol/L，分别。2周龄时血清NOx水平显著高于出生和6周龄时。嗜酸性粒细胞计数,随着肾上腺功能不全而增加，同时测量，为145±199/μL，613±625/μL,466±375/μL,出生时和2、4和6周龄时292±228/μL，分别。这些值表明，嗜酸性粒细胞计数在2周龄时明显高于出生和6周龄时。无绒毛膜羊膜炎的婴儿在4周龄时血清NOx水平显著升高，坏死性小肠结肠炎婴儿的嗜酸性粒细胞计数在2周龄时显著增加。在晚发性循环衰竭的婴儿中未观察到与NOx水平或嗜酸性粒细胞计数相关。
结论：出生后血清NOx水平和嗜酸性粒细胞计数彼此显着相关，并在2周龄时达到峰值。
方法：本研究纳入了19例中位胎龄为27.0周、中位出生体重为888g的极早产儿。出生时和此后每2周测量血清氮氧化物（NOx）水平和外周血嗜酸性粒细胞计数。使用单一标准诊断研究组的发病率。
结果：血清NOx水平（平均值±标准偏差）为22.5±14.9μmol/L，51.2±23.7μmol/L,42.4±15.2μmol/L,出生时和2、4和6周龄时33.8±9.4μmol/L，分别。2周龄时血清NOx水平显著高于出生和6周龄时。嗜酸性粒细胞计数,随着肾上腺功能不全而增加，同时测量，为145±199/μL，613±625/μL,466±375/μL,出生时和2、4和6周龄时292±228/μL，分别。这些值表明，嗜酸性粒细胞计数在2周龄时明显高于出生和6周龄时。无绒毛膜羊膜炎的婴儿在4周龄时血清NOx水平显著升高，坏死性小肠结肠炎婴儿的嗜酸性粒细胞计数在2周龄时显著增加。在晚发性循环衰竭的婴儿中未观察到与NOx水平或嗜酸性粒细胞计数相关。
结论：出生后血清NOx水平和嗜酸性粒细胞计数彼此显着相关，并在2周龄时达到峰值。
