Abstract：
Retrotransposons are transposable elements that are transposed via transcription and reverse transcription. Their copies have accumulated in the genome of mammals, occupying approximately 40% of mammalian genomic mass. These copies are often involved in numerous phenomena, such as chromatin spatial organization, gene expression, development and disease, and have been recognized as a driving force in evolution. Different organisms have gained specific retrotransposon subfamilies and retrotransposed copies, such as hundreds of Mus-specific subfamilies with diverse sequences and genomic locations. Despite this complexity, basic information is still necessary for present-day genomic and epigenomic studies. Herein, we describe the characteristics of each subfamily of Mus-specific retrotransposons in terms of sequence structure, phylogenetic relationships, evolutionary age, and preference for A or B compartments of chromatin.
摘要：
逆转录转座子是通过转录和逆转录转座的可转座元件。它们的拷贝已经积累在哺乳动物的基因组中，约占哺乳动物基因组质量的40%。这些复制品经常涉及许多现象，如染色质空间组织，基因表达，发展和疾病，并被认为是进化的驱动力。不同的生物体获得了特定的反转录转座子亚家族和反转录转座子拷贝，例如数百个具有不同序列和基因组位置的Mus特异性亚家族。尽管复杂,目前的基因组和表观基因组研究仍然需要基本信息。在这里，我们根据序列结构描述了Mus特异性逆转录转座子的每个亚家族的特征，系统发育关系，进化年龄,并且优选染色质的A或B区室。
