%0 Journal Article
%T Mouse retrotransposons: sequence structure, evolutionary age, genomic distribution and function.
%A Kawase M
%A Ichiyanagi K
%J Genes Genet Syst
%V 98
%N 6
%D 2024 Feb 10
%M 37989301
%F 1.258
%R 10.1266/ggs.23-00221
%X Retrotransposons are transposable elements that are transposed via transcription and reverse transcription. Their copies have accumulated in the genome of mammals, occupying approximately 40% of mammalian genomic mass. These copies are often involved in numerous phenomena, such as chromatin spatial organization, gene expression, development and disease, and have been recognized as a driving force in evolution. Different organisms have gained specific retrotransposon subfamilies and retrotransposed copies, such as hundreds of Mus-specific subfamilies with diverse sequences and genomic locations. Despite this complexity, basic information is still necessary for present-day genomic and epigenomic studies. Herein, we describe the characteristics of each subfamily of Mus-specific retrotransposons in terms of sequence structure, phylogenetic relationships, evolutionary age, and preference for A or B compartments of chromatin.