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Abstract：
Explaining the complex structure and dynamics of sleep, which consist of alternating and physiologically distinct nonREM and REM sleep episodes, has posed a significant challenge. In this study, we demonstrate that a single-wave model concept captures the distinctly different overnight dynamics of the four primary sleep measures-the duration and intensity of nonREM and REM sleep episodes-with high quantitative precision for both regular and extended sleep. The model also accurately predicts how these polysomnographic measures respond to sleep deprivation or abundance. Furthermore, the model passes the ultimate test, as its prediction leads to a novel experimental finding-an invariant relationship between the duration of nonREM episodes and the intensity of REM episodes, the product of which remains constant over consecutive sleep cycles. These results suggest a functional unity between nonREM and REM sleep, establishing a comprehensive and quantitative framework for understanding normal sleep and sleep disorders.
摘要：
解释睡眠的复杂结构和动力学，包括交替和生理上不同的非REM和REM睡眠发作，提出了重大挑战。在这项研究中,我们证明,单波模型概念捕获了四种主要睡眠测量的明显不同的夜间动态-非REM和REM睡眠发作的持续时间和强度-对于常规睡眠和延长睡眠均具有较高的定量精度.该模型还准确地预测了这些多导睡眠图测量如何对睡眠剥夺或丰富做出反应。此外，该模型通过了最终测试，因为它的预测导致了一个新的实验发现-非REM发作的持续时间和REM发作的强度之间的不变关系，其乘积在连续的睡眠周期内保持恒定。这些结果表明，非REM和REM睡眠之间存在功能统一，建立一个全面和定量的框架来理解正常的睡眠和睡眠障碍。
