Abstract：
Chlorogenic acid (CGA) is an important bioactive polyphenol with extensive biological properties. This study aimed to fabricate an optimized three-dimensional (3D)-printed capsule scaffold and CGA capsules for targeted delivery of hydrophobic CGA to the colon. The optimized printing parameters identified using the neural network model were a temperature of 170 °C, a printing speed of 20 mm/s, and a nozzle diameter of 0.3 mm. The capsules exhibited slow releasing properties of CGA, and the releasing rates of Eudragit®FS 30D-sealed capsules (due to more cracks and voids) were faster than those of Eudragit®S100-sealed capsules. The Ritger-peppas model was the best fitting model to describe the releasing process of CGA from 8 CGA capsules (R2 ≥ 0.98). All CGA capsules exhibited shear-thinning properties with stable sol-gel viscosity at low shear rates. FTIR spectra confirmed the formation of non-covalent bonds between CGA and the sol. Overall, the obtained 3D-printed capsules provided a promising carrier for the targeted delivery of CGA in the development of personalized dietary supplements.
摘要：
绿原酸（CGA）是一种重要的生物活性多酚，具有广泛的生物学特性。本研究旨在制造优化的三维（3D）打印胶囊支架和CGA胶囊，用于将疏水性CGA靶向递送至结肠。使用神经网络模型确定的优化打印参数是170°C的温度，20毫米/秒的印刷速度，喷嘴直径为0.3mm。胶囊表现出CGA的缓释特性，Eudragit®FS30D密封胶囊的释放速率（由于更多的裂缝和空隙）比Eudragit®S100密封胶囊的释放速率更快。Ritger-peppas模型是描述8个CGA胶囊（R2≥0.98）中CGA释放过程的最佳拟合模型。所有CGA胶囊均表现出剪切稀化特性，在低剪切速率下具有稳定的溶胶-凝胶粘度。FTIR光谱证实在CGA和溶胶之间形成非共价键。总的来说,获得的3D打印胶囊为个性化膳食补充剂的开发中CGA的靶向递送提供了有希望的载体。
