关键词: Cerebellar lesion Inflammatory pseudo tumor Rituxima Splenomegaly

Mesh : Adult Male Child Humans Immunosuppressive Agents Neoplasms Splenectomy Adrenal Cortex Hormones Rituximab

来  源:   DOI:10.1016/j.amjms.2023.11.010

Abstract:
Inflammatory pseudo tumor (IP) is an infrequent process with benign evolution in most cases whose etiology and pathogenesis are unknown. It usually affects young men and children, in whom the macroscopic lesion can mimic a malignant process, which is ruled out after biopsy. Therefore, the diagnosis of certainty is histological and treatment consists of corticosteroids, leaving resection for cases in which biopsy is not possible or in which it produces local complications. We present a case of an inflammatory pseudo tumor with special corticodependence that began as a long-term periodic fever and splenic focal lesion that required splenectomy for its diagnosis and that, after decreasing the corticosteroid regimen, presented recurrences at the cerebellar and systemic level requiring the association of various immunosuppressants and rituximab to achieve remission. As a result of this case, we have performed an analysis of all the pseudo tumors diagnosed in adults in the hospitals of the province of Malaga, and it has been compared with that described in the bibliography.
摘要:
炎性假瘤(IP)是一种罕见的过程,在大多数情况下具有良性演变,其病因和发病机理尚不清楚。它通常影响年轻人和儿童,宏观病变可以模仿恶性过程,这是活检后排除的。因此,确定性的诊断是组织学和治疗包括皮质类固醇,对于无法进行活检或产生局部并发症的病例,保留切除。我们介绍了一个具有特殊皮质依赖性的炎性假瘤的病例,该病例始于长期的周期性发烧和脾局灶性病变,需要脾切除术来诊断,在减少皮质类固醇方案后,在小脑和全身水平出现复发,需要联合各种免疫抑制剂和利妥昔单抗来实现缓解。由于这个案子,我们在马拉加省的医院对成人诊断出的所有假瘤进行了分析,并与参考书目中描述的进行了比较。
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