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Abstract：
OBJECTIVE: To investigate the morphological characteristics of Bergmeister papilla (BMP), a persistent hyaloid remnant tissue, and its effects on the measurements and repeatability of spectral-domain optical coherence tomography (OCT).
METHODS: The subjects of this prospective cross-sectional study including 83 patients with BMP and 76 unaffected individuals, all had open-angle structures. Images, including a 5-line raster and three consecutive optic disc cube scans centred on the optic disc, were acquired using the Cirrus high-definition OCT. BMP\'s structural characteristics were classified based on the raster scan images, and repeatability of acquiring optic nerve head and retinal nerve fibre layer parameters acquisition was analysed by calculating the test-retest standard deviation (Sw), coefficient of variance (CV), and intraclass correlation coefficient.
RESULTS: BMPs (n = 83) were categorised into lifting edge (LE) type (63.9%, n = 53), which partially covers the edge of the optic nerve head, and covering disc (CD) type (36.1%, n = 30), which completely covers the cupping area like a cap. The average cup-to-disc ratio (0.58 ± 0.21), vertical cup-to-disc ratio (0.55 ± 0.21), and cup volume (0.22 ± 0.22) of the CD type were lower than those of the LE type (0.66 ± 0.13, 0.64 ± 0.13, and 0.4 ± 0.27, respectively; all P < 0.05). Tolerability indices for repeatability of cup volume (Sw = 0.40 and CV = 0.36) and inferonasal (4 o\'clock) retinal nerve fibre layer (Sw = 0.27 and CV = 0.25) in LE-type BMPs exceeded the cut-off value (0.22) and demonstrated stronger correlation with BMP location than that of the controls.
CONCLUSIONS: Caution should be exercised when interpreting OCT findings in eyes with BMP, as BMP can introduce a pitfall in OCT imaging.
METHODS: The subjects of this prospective cross-sectional study including 83 patients with BMP and 76 unaffected individuals, all had open-angle structures. Images, including a 5-line raster and three consecutive optic disc cube scans centred on the optic disc, were acquired using the Cirrus high-definition OCT. BMP\'s structural characteristics were classified based on the raster scan images, and repeatability of acquiring optic nerve head and retinal nerve fibre layer parameters acquisition was analysed by calculating the test-retest standard deviation (Sw), coefficient of variance (CV), and intraclass correlation coefficient.
RESULTS: BMPs (n = 83) were categorised into lifting edge (LE) type (63.9%, n = 53), which partially covers the edge of the optic nerve head, and covering disc (CD) type (36.1%, n = 30), which completely covers the cupping area like a cap. The average cup-to-disc ratio (0.58 ± 0.21), vertical cup-to-disc ratio (0.55 ± 0.21), and cup volume (0.22 ± 0.22) of the CD type were lower than those of the LE type (0.66 ± 0.13, 0.64 ± 0.13, and 0.4 ± 0.27, respectively; all P < 0.05). Tolerability indices for repeatability of cup volume (Sw = 0.40 and CV = 0.36) and inferonasal (4 o\'clock) retinal nerve fibre layer (Sw = 0.27 and CV = 0.25) in LE-type BMPs exceeded the cut-off value (0.22) and demonstrated stronger correlation with BMP location than that of the controls.
CONCLUSIONS: Caution should be exercised when interpreting OCT findings in eyes with BMP, as BMP can introduce a pitfall in OCT imaging.
摘要：
目的：研究Bergmeister乳头（BMP）的形态特征，持久的玻璃样残余组织，及其对谱域光学相干断层扫描（OCT）的测量和可重复性的影响。
方法：这项前瞻性横断面研究的受试者包括83例BMP患者和76例未受影响的个体，都有开角结构。Images,包括一个5线光栅和三个以光盘为中心的连续光盘立方体扫描，是使用Cirrus高清OCT获得的。基于光栅扫描图像对BMP的结构特征进行了分类，通过计算重测标准偏差(Sw)分析获取视神经乳头和视网膜神经纤维层参数的可重复性,变异系数(CV)，和组内相关系数。
结果：BMP（n=83）被归类为提升边缘（LE）类型（63.9％，n=53),部分覆盖了视神经头的边缘，和覆盖光盘(CD)类型(36.1%，n=30),像帽子一样完全覆盖了拔罐区域。平均杯盘比（0.58±0.21），垂直杯盘比（0.55±0.21），CD型和杯容积（0.22±0.22）低于LE型（分别为0.66±0.13、0.64±0.13和0.4±0.27；均P<0.05）。LE型BMP中杯容量（Sw=0.40和CV=0.36）和鼻下（4点）视网膜神经纤维层（Sw=0.27和CV=0.25）的可重复性的耐受性指数超过了临界值（0.22），并且与BMP位置的相关性比对照更强。
结论：在使用BMP解释眼睛的OCT发现时应谨慎，因为BMP会在OCT成像中引入缺陷。
方法：这项前瞻性横断面研究的受试者包括83例BMP患者和76例未受影响的个体，都有开角结构。Images,包括一个5线光栅和三个以光盘为中心的连续光盘立方体扫描，是使用Cirrus高清OCT获得的。基于光栅扫描图像对BMP的结构特征进行了分类，通过计算重测标准偏差(Sw)分析获取视神经乳头和视网膜神经纤维层参数的可重复性,变异系数(CV)，和组内相关系数。
结果：BMP（n=83）被归类为提升边缘（LE）类型（63.9％，n=53),部分覆盖了视神经头的边缘，和覆盖光盘(CD)类型(36.1%，n=30),像帽子一样完全覆盖了拔罐区域。平均杯盘比（0.58±0.21），垂直杯盘比（0.55±0.21），CD型和杯容积（0.22±0.22）低于LE型（分别为0.66±0.13、0.64±0.13和0.4±0.27；均P<0.05）。LE型BMP中杯容量（Sw=0.40和CV=0.36）和鼻下（4点）视网膜神经纤维层（Sw=0.27和CV=0.25）的可重复性的耐受性指数超过了临界值（0.22），并且与BMP位置的相关性比对照更强。
结论：在使用BMP解释眼睛的OCT发现时应谨慎，因为BMP会在OCT成像中引入缺陷。
