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Abstract：
To investigate the prognostic significance of optic atrophy 1 (OPA1) in pan-cancer and analyze the relationship between OPA1 and immune infiltration in cancer.
OPA1 exhibited high expression levels or mutations in various types of tumor cells, and its expression levels were significantly correlated with the survival rate of tumor patients. In different tumor tissues, there was a notable positive correlation between OPA1 expression levels and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Additionally, OPA1 and its related genes were found to be involved in several crucial biological processes, including protein phosphorylation, protein import into the nucleus, and protein binding.
OPA1 is highly expressed or mutated in numerous tumors and is strongly associated with protein phosphorylation, patient prognosis, and immune cell infiltration. OPA1 holds promise as a novel prognostic marker with potential clinical utility across various tumor types.
We examined OPA1 expression in pan-cancer at both the gene and protein levels using various databases, including Tumor Immune Estimation Resource 2.0 (TIMER 2.0), Gene Expression Profiling Interactive Analysis (GEPIA2), UALCAN, and The Human Protein Atlas (HPA). We utilized the Kaplan-Meier plotter and GEPIA datasets to analyze the relationship between OPA1 expression levels and patient prognosis. Through the cBioPortal database, we detected OPA1 mutations in tumors and examined their relationship with patient prognosis. We employed the TIMER 2.0 database to explore the correlation between OPA1 expression levels in tumor tissue and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Furthermore, we conducted a gene search associated with OPA1 and performed enrichment analysis to identify the main signaling pathways and biological processes linked to them.
OPA1 exhibited high expression levels or mutations in various types of tumor cells, and its expression levels were significantly correlated with the survival rate of tumor patients. In different tumor tissues, there was a notable positive correlation between OPA1 expression levels and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Additionally, OPA1 and its related genes were found to be involved in several crucial biological processes, including protein phosphorylation, protein import into the nucleus, and protein binding.
OPA1 is highly expressed or mutated in numerous tumors and is strongly associated with protein phosphorylation, patient prognosis, and immune cell infiltration. OPA1 holds promise as a novel prognostic marker with potential clinical utility across various tumor types.
We examined OPA1 expression in pan-cancer at both the gene and protein levels using various databases, including Tumor Immune Estimation Resource 2.0 (TIMER 2.0), Gene Expression Profiling Interactive Analysis (GEPIA2), UALCAN, and The Human Protein Atlas (HPA). We utilized the Kaplan-Meier plotter and GEPIA datasets to analyze the relationship between OPA1 expression levels and patient prognosis. Through the cBioPortal database, we detected OPA1 mutations in tumors and examined their relationship with patient prognosis. We employed the TIMER 2.0 database to explore the correlation between OPA1 expression levels in tumor tissue and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Furthermore, we conducted a gene search associated with OPA1 and performed enrichment analysis to identify the main signaling pathways and biological processes linked to them.
摘要：
目的：探讨视神经萎缩1（OPA1）在泛癌症中的预后意义，并分析OPA1与癌症免疫浸润的关系。
结果：OPA1在各种类型的肿瘤细胞中呈现高表达水平或突变，其表达水平与肿瘤患者的生存率显著相关。在不同的肿瘤组织中，OPA1表达水平与免疫微环境中癌相关成纤维细胞的浸润呈显著正相关。此外,OPA1及其相关基因被发现参与几个关键的生物学过程，包括蛋白质磷酸化，蛋白质导入细胞核，和蛋白质结合。
结论：OPA1在许多肿瘤中高表达或突变，并且与蛋白质磷酸化密切相关，患者预后,和免疫细胞浸润。OPA1有望作为一种新型的预后标志物，在各种肿瘤类型中具有潜在的临床应用。
方法：我们使用各种数据库在基因和蛋白质水平上检测了OPA1在泛癌症中的表达，包括肿瘤免疫评估资源2.0(TIMER2.0)，基因表达谱交互式分析（GEPIA2），UALCAN,和人蛋白质图谱(HPA)。我们利用Kaplan-Meier绘图仪和GEPIA数据集来分析OPA1表达水平与患者预后之间的关系。通过cBioPortal数据库,我们检测了肿瘤中的OPA1突变,并检查了其与患者预后的关系.我们使用TIMER2.0数据库来探索肿瘤组织中OPA1表达水平与免疫微环境中癌症相关成纤维细胞浸润之间的相关性。此外，我们进行了与OPA1相关的基因搜索,并进行了富集分析,以鉴定与其相关的主要信号通路和生物学过程.
结果：OPA1在各种类型的肿瘤细胞中呈现高表达水平或突变，其表达水平与肿瘤患者的生存率显著相关。在不同的肿瘤组织中，OPA1表达水平与免疫微环境中癌相关成纤维细胞的浸润呈显著正相关。此外,OPA1及其相关基因被发现参与几个关键的生物学过程，包括蛋白质磷酸化，蛋白质导入细胞核，和蛋白质结合。
结论：OPA1在许多肿瘤中高表达或突变，并且与蛋白质磷酸化密切相关，患者预后,和免疫细胞浸润。OPA1有望作为一种新型的预后标志物，在各种肿瘤类型中具有潜在的临床应用。
方法：我们使用各种数据库在基因和蛋白质水平上检测了OPA1在泛癌症中的表达，包括肿瘤免疫评估资源2.0(TIMER2.0)，基因表达谱交互式分析（GEPIA2），UALCAN,和人蛋白质图谱(HPA)。我们利用Kaplan-Meier绘图仪和GEPIA数据集来分析OPA1表达水平与患者预后之间的关系。通过cBioPortal数据库,我们检测了肿瘤中的OPA1突变,并检查了其与患者预后的关系.我们使用TIMER2.0数据库来探索肿瘤组织中OPA1表达水平与免疫微环境中癌症相关成纤维细胞浸润之间的相关性。此外，我们进行了与OPA1相关的基因搜索,并进行了富集分析,以鉴定与其相关的主要信号通路和生物学过程.
