Abstract：
OBJECTIVE: The purpose of this study was to systematically review the evidence in the literature in order to evaluate the outcomes following medial patellofemoral ligament (MPFL) reconstruction with allograft compared to autograft reconstruction.
METHODS: A systematic literature search was performed based on PRISMA guidelines using the EMBASE, MEDLINE, and The Cochrane Library databases. Inclusion criteria for the study was clinical studies reporting on MPFL reconstruction with allograft. Recurrence rate, complications, rate of return-to-play, and functional outcomes including the Kujala, Tegner, and visual analog scale (VAS) scores were evaluated. Statistical analysis was performed using GraphPad Prism 8.3.
RESULTS: Our review identified 12 studies with a total of 336 patient knees meeting the inclusion criteria. The majority of patients were female (61.6%), with a mean age of 22.3 years and a mean follow-up of 43.4 months. The overall rate of recurrence of lateral patellar instability was 2.7% in the allograft cohort as compared to 7.8% in the autograft cohort (p = 0.01). The mean Kujala score was 91.8%, and the mean VAS score was 1.3 at final follow-up. Additionally, 81.5% of patients were able to return to play in the studies reporting this outcome measure. The overall complication rate was 1.4%.
CONCLUSIONS: The overall rate of recurrence was lower following MPFL reconstruction with allograft as compared to autograft in the treatment of lateral patellar instability. Additionally, there were excellent patient reported outcomes and a low complication rate following the use of allograft for MPFL reconstructionPurpose: The purpose of this study was to systematically review the evidence in the literature in order to evaluate the outcomes following medial patellofemoral ligament (MPFL) reconstruction with allograft compared to autograft reconstruction.
METHODS: A systematic literature search was performed based on PRISMA guidelines using the EMBASE, MEDLINE, and The Cochrane Library databases. Inclusion criteria for the study was clinical studies reporting on MPFL reconstruction with allograft. Recurrence rate, complications, rate of return-to-play, and functional outcomes including the Kujala, Tegner, and visual analog scale (VAS) scores were evaluated. Statistical analysis was performed using GraphPad Prism 8.3.
RESULTS: Our review identified 12 studies with a total of 336 patient knees meeting the inclusion criteria. The majority of patients were female (61.6%), with a mean age of 22.3 years and a mean follow-up of 43.4 months. The overall rate of recurrence of lateral patellar instability was 2.7% in the allograft cohort as compared to 7.8% in the autograft cohort (p = 0.01). The mean Kujala score was 91.8%, and the mean VAS score was 1.3 at final follow-up. Additionally, 81.5% of patients were able to return to play in the studies reporting this outcome measure. The overall complication rate was 1.4%.
CONCLUSIONS: The overall rate of recurrence was lower following MPFL reconstruction with allograft as compared to autograft in the treatment of lateral patellar instability. Additionally, there were excellent patient reported outcomes and a low complication rate following the use of allograft for MPFL reconstruction.
METHODS: A systematic literature search was performed based on PRISMA guidelines using the EMBASE, MEDLINE, and The Cochrane Library databases. Inclusion criteria for the study was clinical studies reporting on MPFL reconstruction with allograft. Recurrence rate, complications, rate of return-to-play, and functional outcomes including the Kujala, Tegner, and visual analog scale (VAS) scores were evaluated. Statistical analysis was performed using GraphPad Prism 8.3.
RESULTS: Our review identified 12 studies with a total of 336 patient knees meeting the inclusion criteria. The majority of patients were female (61.6%), with a mean age of 22.3 years and a mean follow-up of 43.4 months. The overall rate of recurrence of lateral patellar instability was 2.7% in the allograft cohort as compared to 7.8% in the autograft cohort (p = 0.01). The mean Kujala score was 91.8%, and the mean VAS score was 1.3 at final follow-up. Additionally, 81.5% of patients were able to return to play in the studies reporting this outcome measure. The overall complication rate was 1.4%.
CONCLUSIONS: The overall rate of recurrence was lower following MPFL reconstruction with allograft as compared to autograft in the treatment of lateral patellar instability. Additionally, there were excellent patient reported outcomes and a low complication rate following the use of allograft for MPFL reconstructionPurpose: The purpose of this study was to systematically review the evidence in the literature in order to evaluate the outcomes following medial patellofemoral ligament (MPFL) reconstruction with allograft compared to autograft reconstruction.
METHODS: A systematic literature search was performed based on PRISMA guidelines using the EMBASE, MEDLINE, and The Cochrane Library databases. Inclusion criteria for the study was clinical studies reporting on MPFL reconstruction with allograft. Recurrence rate, complications, rate of return-to-play, and functional outcomes including the Kujala, Tegner, and visual analog scale (VAS) scores were evaluated. Statistical analysis was performed using GraphPad Prism 8.3.
RESULTS: Our review identified 12 studies with a total of 336 patient knees meeting the inclusion criteria. The majority of patients were female (61.6%), with a mean age of 22.3 years and a mean follow-up of 43.4 months. The overall rate of recurrence of lateral patellar instability was 2.7% in the allograft cohort as compared to 7.8% in the autograft cohort (p = 0.01). The mean Kujala score was 91.8%, and the mean VAS score was 1.3 at final follow-up. Additionally, 81.5% of patients were able to return to play in the studies reporting this outcome measure. The overall complication rate was 1.4%.
CONCLUSIONS: The overall rate of recurrence was lower following MPFL reconstruction with allograft as compared to autograft in the treatment of lateral patellar instability. Additionally, there were excellent patient reported outcomes and a low complication rate following the use of allograft for MPFL reconstruction.
摘要：
目的：本研究的目的是系统回顾文献中的证据，以评估同种异体移植重建内侧髌股韧带（MPFL）后与自体移植重建后的结果。
方法：根据PRISMA指南使用EMBASE进行了系统的文献检索，MEDLINE,和Cochrane图书馆数据库。该研究的纳入标准是报道同种异体移植MPFL重建的临床研究。复发率,并发症,回归率，和功能结果，包括Kujala，Tegner,评价视觉模拟量表(VAS)评分。使用GraphPadPrism8.3进行统计分析。
结果：我们的综述确定了12项研究，总共336例患者的膝盖符合纳入标准。大多数患者为女性（61.6％），平均年龄22.3岁，平均随访43.4个月。同种异体移植队列中髌骨外侧不稳定的总复发率为2.7％，而自体移植队列中为7.8％（p=0.01）。Kujala平均得分为91.8%,最终随访时平均VAS评分为1.3.此外,81.5%的患者能够在报告这一结果指标的研究中恢复比赛。总并发症发生率为1.4%。
结论：与自体移植治疗髌骨外侧不稳定相比，同种异体移植重建MPFL后的总复发率较低。此外,使用同种异体移植物进行MPFL重建后，患者报告的结果良好，并发症发生率低。目的：本研究的目的是系统地回顾文献中的证据，以评估同种异体移植物重建内侧髌股韧带（MPFL）后的结果。
方法：根据PRISMA指南使用EMBASE进行了系统的文献检索，MEDLINE,和Cochrane图书馆数据库。该研究的纳入标准是报道同种异体移植MPFL重建的临床研究。复发率,并发症,回归率，和功能结果，包括Kujala，Tegner,评价视觉模拟量表(VAS)评分。使用GraphPadPrism8.3进行统计分析。
结果：我们的综述确定了12项研究，总共336例患者的膝盖符合纳入标准。大多数患者为女性（61.6％），平均年龄22.3岁，平均随访43.4个月。同种异体移植队列中髌骨外侧不稳定的总复发率为2.7％，而自体移植队列中为7.8％（p=0.01）。Kujala平均得分为91.8%,最终随访时平均VAS评分为1.3.此外,81.5%的患者能够在报告这一结果指标的研究中恢复比赛。总并发症发生率为1.4%。
结论：与自体移植治疗髌骨外侧不稳定相比，同种异体移植重建MPFL后的总复发率较低。此外,在使用同种异体移植进行MPFL重建后,患者报告的结局优异,并发症发生率低.
方法：根据PRISMA指南使用EMBASE进行了系统的文献检索，MEDLINE,和Cochrane图书馆数据库。该研究的纳入标准是报道同种异体移植MPFL重建的临床研究。复发率,并发症,回归率，和功能结果，包括Kujala，Tegner,评价视觉模拟量表(VAS)评分。使用GraphPadPrism8.3进行统计分析。
结果：我们的综述确定了12项研究，总共336例患者的膝盖符合纳入标准。大多数患者为女性（61.6％），平均年龄22.3岁，平均随访43.4个月。同种异体移植队列中髌骨外侧不稳定的总复发率为2.7％，而自体移植队列中为7.8％（p=0.01）。Kujala平均得分为91.8%,最终随访时平均VAS评分为1.3.此外,81.5%的患者能够在报告这一结果指标的研究中恢复比赛。总并发症发生率为1.4%。
结论：与自体移植治疗髌骨外侧不稳定相比，同种异体移植重建MPFL后的总复发率较低。此外,使用同种异体移植物进行MPFL重建后，患者报告的结果良好，并发症发生率低。目的：本研究的目的是系统地回顾文献中的证据，以评估同种异体移植物重建内侧髌股韧带（MPFL）后的结果。
方法：根据PRISMA指南使用EMBASE进行了系统的文献检索，MEDLINE,和Cochrane图书馆数据库。该研究的纳入标准是报道同种异体移植MPFL重建的临床研究。复发率,并发症,回归率，和功能结果，包括Kujala，Tegner,评价视觉模拟量表(VAS)评分。使用GraphPadPrism8.3进行统计分析。
结果：我们的综述确定了12项研究，总共336例患者的膝盖符合纳入标准。大多数患者为女性（61.6％），平均年龄22.3岁，平均随访43.4个月。同种异体移植队列中髌骨外侧不稳定的总复发率为2.7％，而自体移植队列中为7.8％（p=0.01）。Kujala平均得分为91.8%,最终随访时平均VAS评分为1.3.此外,81.5%的患者能够在报告这一结果指标的研究中恢复比赛。总并发症发生率为1.4%。
结论：与自体移植治疗髌骨外侧不稳定相比，同种异体移植重建MPFL后的总复发率较低。此外,在使用同种异体移植进行MPFL重建后,患者报告的结局优异,并发症发生率低.
