PDF(Pubmed)
Abstract：
BACKGROUND: The neuropeptide oxytocin (OT) is crucial in several conditions, such as lactation, parturition, mother-infant interaction, and psychosocial function. Moreover, OT may be involved in the regulation of eating behaviors.
METHODS: This review briefly summarizes data concerning the role of OT in eating behaviors. Appropriate keywords and medical subject headings were identified and searched for in PubMed/MEDLINE. References of original articles and reviews were screened, examined, and selected.
RESULTS: Hypothalamic OT-secreting neurons project to different cerebral areas controlling eating behaviors, such as the amygdala, area postrema, nucleus of the solitary tract, and dorsal motor nucleus of the vagus nerve. Intracerebral/ventricular OT administration decreases food intake and body weight in wild and genetically obese rats. OT may alter food intake and the quality of meals, especially carbohydrates and sweets, in humans.
CONCLUSIONS: OT may play a role in the pathophysiology of eating disorders with potential therapeutic perspectives. In obese patients and those with certain eating disorders, such as bulimia nervosa or binge/compulsive eating, OT may reduce appetite and caloric consumption. Conversely, OT administered to patients with anorexia nervosa may paradoxically stimulate appetite, possibly by lowering anxiety which usually complicates the management of these patients. Nevertheless, OT administration (e.g., intranasal route) is not always associated with clinical benefit, probably because intranasally administered OT fails to achieve therapeutic intracerebral levels of the hormone.
CONCLUSIONS: OT administration could play a therapeutic role in managing eating disorders and disordered eating. However, specific studies are needed to clarify this issue with regard to dose-finding and route and administration time.
METHODS: This review briefly summarizes data concerning the role of OT in eating behaviors. Appropriate keywords and medical subject headings were identified and searched for in PubMed/MEDLINE. References of original articles and reviews were screened, examined, and selected.
RESULTS: Hypothalamic OT-secreting neurons project to different cerebral areas controlling eating behaviors, such as the amygdala, area postrema, nucleus of the solitary tract, and dorsal motor nucleus of the vagus nerve. Intracerebral/ventricular OT administration decreases food intake and body weight in wild and genetically obese rats. OT may alter food intake and the quality of meals, especially carbohydrates and sweets, in humans.
CONCLUSIONS: OT may play a role in the pathophysiology of eating disorders with potential therapeutic perspectives. In obese patients and those with certain eating disorders, such as bulimia nervosa or binge/compulsive eating, OT may reduce appetite and caloric consumption. Conversely, OT administered to patients with anorexia nervosa may paradoxically stimulate appetite, possibly by lowering anxiety which usually complicates the management of these patients. Nevertheless, OT administration (e.g., intranasal route) is not always associated with clinical benefit, probably because intranasally administered OT fails to achieve therapeutic intracerebral levels of the hormone.
CONCLUSIONS: OT administration could play a therapeutic role in managing eating disorders and disordered eating. However, specific studies are needed to clarify this issue with regard to dose-finding and route and administration time.
摘要：
背景：神经肽催产素（OT）在几种情况下至关重要，如哺乳，分娩,母婴互动，和心理社会功能。此外，OT可能参与饮食行为的调节。
方法：这篇综述简要总结了有关OT在饮食行为中的作用的数据。在PubMed/MEDLINE中识别并搜索适当的关键词和医学主题词。对原始文章和评论的参考文献进行了筛选，检查,并选择。
结果：下丘脑分泌OT的神经元投射到控制进食行为的不同大脑区域，比如杏仁核,区域后，孤束核，和迷走神经的背侧运动核。脑内/脑室OT给药可降低野生和遗传肥胖大鼠的食物摄入量和体重。OT可能会改变食物摄入量和膳食质量，尤其是碳水化合物和甜食,在人类中。
结论：OT可能在进食障碍的病理生理学中起作用，具有潜在的治疗前景。在肥胖患者和某些饮食失调的患者中，如神经性暴食症或暴饮暴食/强迫性进食，OT可能会降低食欲和热量消耗。相反，给予神经性厌食症患者OT可能矛盾地刺激食欲，可能是通过降低焦虑，而焦虑通常会使这些患者的管理复杂化。然而，OT管理(例如，鼻内途径)并不总是与临床获益相关，可能是因为鼻内给予OT未能达到治疗性脑内水平的激素。
结论：OT给药可以在控制饮食失调和饮食失调方面发挥治疗作用。然而,需要具体的研究来澄清剂量发现,给药途径和给药时间方面的问题.
方法：这篇综述简要总结了有关OT在饮食行为中的作用的数据。在PubMed/MEDLINE中识别并搜索适当的关键词和医学主题词。对原始文章和评论的参考文献进行了筛选，检查,并选择。
结果：下丘脑分泌OT的神经元投射到控制进食行为的不同大脑区域，比如杏仁核,区域后，孤束核，和迷走神经的背侧运动核。脑内/脑室OT给药可降低野生和遗传肥胖大鼠的食物摄入量和体重。OT可能会改变食物摄入量和膳食质量，尤其是碳水化合物和甜食,在人类中。
结论：OT可能在进食障碍的病理生理学中起作用，具有潜在的治疗前景。在肥胖患者和某些饮食失调的患者中，如神经性暴食症或暴饮暴食/强迫性进食，OT可能会降低食欲和热量消耗。相反，给予神经性厌食症患者OT可能矛盾地刺激食欲，可能是通过降低焦虑，而焦虑通常会使这些患者的管理复杂化。然而，OT管理(例如，鼻内途径)并不总是与临床获益相关，可能是因为鼻内给予OT未能达到治疗性脑内水平的激素。
结论：OT给药可以在控制饮食失调和饮食失调方面发挥治疗作用。然而,需要具体的研究来澄清剂量发现,给药途径和给药时间方面的问题.
