Abstract：
Silks fibroin can be chemically modified through amino acid side chains to obtain methacrylated silk (Sil-MA). Sil-MA could be processed into a variety of scaffold forms and combine synergistically with other biomaterials to form composites vehicle. The advent of Sil-MA material has enabled impressive progress in the development of various scaffolds based on Sil-MA type to imitate the structural and functional characteristics of natural tissues. This review highlights the reasonable design and bio-fabrication strategies of diverse Sil-MA-based tissue constructs for regenerative medicine. First, we elucidate modification methodology and characteristics of Sil-MA. Next, we describe characteristics of Sil-MA hydrogels, and focus on the design approaches and formation of different types of Sil-MA-based hydrogels. Thereafter, we present an overview of the recent advances in the application of Sil-MA based scaffolds for regenerative medicine, including detailed strategies for the engineering methods and materials used. Finally, we summarize the current research progress and future directions of Sil-MA in regenerative medicine. This review not only delineates the representative design strategies and their application in regenerative medicine, but also provides new direction in the fabrication of biomaterial constructs for the clinical translation in order to stimulate the future development of implants.
摘要：
丝丝素蛋白可以通过氨基酸侧链进行化学修饰以获得甲基丙烯酸酯化的丝(Sil-MA)。Sil-MA可以加工成多种支架形式，并与其他生物材料协同结合，形成复合材料载体。Sil-MA材料的出现使基于Sil-MA类型的各种支架的开发取得了令人印象深刻的进展，以模仿天然组织的结构和功能特征。这篇综述强调了用于再生医学的各种基于Sil-MA的组织构建体的合理设计和生物制造策略。首先,我们阐明了Sil-MA的修饰方法和特点。接下来,我们描述了Sil-MA水凝胶的特征，并重点介绍了不同类型的Sil-MA基水凝胶的设计方法和形成。此后,我们概述了基于Sil-MA的支架在再生医学中的应用的最新进展，包括工程方法和材料的详细策略。最后,本文综述了Sil-MA在再生医学领域的研究进展及未来发展方向。这篇综述不仅概述了具有代表性的设计策略及其在再生医学中的应用，同时也为生物材料构建体的临床转化提供了新的方向，以刺激植入物的未来发展。
