PDF(Pubmed)
Abstract：
OBJECTIVE: Engineered lysins are considered as highly promising alternatives for antibiotics. Our previous screening study using VersaTile technology identified 1D10 as a possible lead compound with activity against Acinetobacter baumannii strains under elevated human serum concentrations. In this manuscript, we reveal an unexpected mode of action and exceptional thermoresistance for lysin 1D10. Our findings shed new light on the development of engineered lysins, providing valuable insights for future research in this field.
摘要：
目的：工程溶素被认为是非常有前途的抗生素替代品。我们先前使用VersaTile技术的筛选研究将1D10鉴定为可能的先导化合物，在升高的人血清浓度下具有针对鲍曼不动杆菌菌株的活性。在这份手稿中,我们揭示了lysin1D10的意想不到的作用方式和特殊的耐热性。我们的发现为工程溶素的开发提供了新的思路，为该领域的未来研究提供有价值的见解。
