PDF(Pubmed)
Abstract：
We performed in vitro antifungal susceptibility testing of manogepix against the yeast phase of 78 Emergomyces africanus, 2 Emergomyces pasteurianus, and 5 Blastomyces emzantsi isolates using a reference broth microdilution method following Clinical and Laboratory Standards Institute recommendations. All three pathogens had low minimum inhibitory concentrations ranging from <0.0005 to 0.008 mg/L. Manogepix should be investigated in animal models and potentially in future human clinical trials for endemic mycoses.
摘要：
我们进行了体外抗真菌药敏试验manogepix对78种非洲产卵酵母的酵母期，2巴斯德氏菌，根据临床和实验室标准研究所的建议，使用参考肉汤微量稀释法分离5株胚芽菌。所有三种病原体的最低抑制浓度均低于0.0005至0.008mg/L。Manogepix应在动物模型中进行研究，并可能在未来的地方性真菌病人体临床试验中进行研究。
