PDF(Pubmed)
Abstract：
Nanomaterials, specifically metal nanoclusters (NCs), are gaining attention as a promising class of antibacterial agents. Metal NCs exhibit antibacterial properties due to their ultrasmall size, extensive surface area, and well-controlled surface ligands. The antibacterial mechanisms of metal NCs are influenced by two primary factors: size and surface charge. In this review, we summarize the impacts of size and surface charge of metal NCs on the antibacterial mechanisms, their interactions with bacteria, and the factors that influence their antibacterial effects against both gram-negative and gram-positive bacteria. Additionally, we highlight the mechanisms that occur when NCs are negatively or positively charged, and provide examples of their applications as antibacterial agents. A better understanding of relationships between antibacterial activity and the properties of metal NCs will aid in the design and synthesis of nanomaterials for the development of effective antibacterial agents against bacterial infections. Based on the remarkable achievements in the design of metal NCs, this review also presents conclusions on current challenges and future perspectives of metal NCs for both fundamental investigations and practical antibacterial applications.
摘要：
纳米材料,特别是金属纳米簇(NC)，作为一类有前途的抗菌剂越来越受到关注。金属NC由于其超小的尺寸而表现出抗菌性能，广泛的表面积，和良好控制的表面配体。金属NC的抗菌机制受两个主要因素的影响：尺寸和表面电荷。在这次审查中,我们总结了金属NCs的大小和表面电荷对抗菌机制的影响，它们与细菌的相互作用，以及影响其对革兰氏阴性菌和革兰氏阳性菌的抗菌作用的因素。此外,我们强调了当NC带负电荷或正电荷时发生的机制，并提供了它们作为抗菌剂的应用实例。更好地了解抗菌活性与金属NC的性质之间的关系将有助于纳米材料的设计和合成，以开发针对细菌感染的有效抗菌剂。在金属NC设计取得显著成就的基础上，这篇综述还提出了关于金属NC在基础研究和实际抗菌应用方面的当前挑战和未来前景的结论。
