Abstract：
BACKGROUND: This study aimed to develop a postnatal treatment strategy for infants with prenatally diagnosed congenital biliary dilatation.
METHODS: We performed a retrospective study of patients with prenatal diagnosed congenital biliary dilatation (CBD), aged <1 year who underwent surgery at our hospital between 2013 and 2023. We classified the patients into two groups, the \"early group,\" consisting of patients who could not wait for growth, and required early surgery, and the \"scheduled group,\" consisting of patients who were asymptomatic and could undergo scheduled surgery, and compared them. The parameters for early surgical prediction were AST, ALT, TB, DB, and CRP levels at birth, 1 week, 2 weeks, 1 month, 2 months, and 3 months after birth, and immediately before surgery, as well as the cyst diameter, presence of intrahepatic bile duct dilation, and presence of debris in the common bile duct.
RESULTS: During the study period, 15 patients were diagnosed prenatally. The cyst diameter was significantly larger at all points in the early group. Patients with a cyst diameter of >30 mm at birth, intrahepatic bile duct dilatation at birth, and postnatal enlargement of the common bile duct to >30 mm are more likely to develop symptoms early. Blood biochemistry tests showed no significant differences between the two groups.
CONCLUSIONS: Patients with a cyst diameter >30 mm in the early postnatal period require careful postnatal management and parents should be counseled regarding the high likelihood of their child needing surgery within the first 3 months of life.
METHODS: Level IV.
METHODS: We performed a retrospective study of patients with prenatal diagnosed congenital biliary dilatation (CBD), aged <1 year who underwent surgery at our hospital between 2013 and 2023. We classified the patients into two groups, the \"early group,\" consisting of patients who could not wait for growth, and required early surgery, and the \"scheduled group,\" consisting of patients who were asymptomatic and could undergo scheduled surgery, and compared them. The parameters for early surgical prediction were AST, ALT, TB, DB, and CRP levels at birth, 1 week, 2 weeks, 1 month, 2 months, and 3 months after birth, and immediately before surgery, as well as the cyst diameter, presence of intrahepatic bile duct dilation, and presence of debris in the common bile duct.
RESULTS: During the study period, 15 patients were diagnosed prenatally. The cyst diameter was significantly larger at all points in the early group. Patients with a cyst diameter of >30 mm at birth, intrahepatic bile duct dilatation at birth, and postnatal enlargement of the common bile duct to >30 mm are more likely to develop symptoms early. Blood biochemistry tests showed no significant differences between the two groups.
CONCLUSIONS: Patients with a cyst diameter >30 mm in the early postnatal period require careful postnatal management and parents should be counseled regarding the high likelihood of their child needing surgery within the first 3 months of life.
METHODS: Level IV.
摘要：
背景：本研究旨在为产前诊断为先天性胆道扩张的婴儿制定一种产后治疗策略。
方法：我们对产前诊断为先天性胆道扩张（CBD）的患者进行了回顾性研究，年龄<1岁，2013年至2023年在我们医院接受手术。我们把病人分成两组,“早期组，“由等不及成长的病人组成，需要早期手术，和“预定的组，“由无症状并可以接受预定手术的患者组成，比较它们。早期手术预测的参数是AST，ALT,TB,DB,和出生时的CRP水平，1周,2周,1个月,2个月,出生后三个月，手术前，以及囊肿直径，肝内胆管扩张的存在，胆总管内有碎片.
结果：在研究期间，15例产前诊断。早期组的所有点的囊肿直径均显着较大。出生时囊肿直径>30毫米的患者，出生时肝内胆管扩张，出生后胆总管增大至>30mm更容易出现早期症状。血液生化测试显示两组之间没有显着差异。
结论：出生后早期囊肿直径>30mm的患者需要仔细的产后管理，父母应该被告知他们的孩子在出生后的头3个月内需要手术的可能性很高。
方法：四级。
方法：我们对产前诊断为先天性胆道扩张（CBD）的患者进行了回顾性研究，年龄<1岁，2013年至2023年在我们医院接受手术。我们把病人分成两组,“早期组，“由等不及成长的病人组成，需要早期手术，和“预定的组，“由无症状并可以接受预定手术的患者组成，比较它们。早期手术预测的参数是AST，ALT,TB,DB,和出生时的CRP水平，1周,2周,1个月,2个月,出生后三个月，手术前，以及囊肿直径，肝内胆管扩张的存在，胆总管内有碎片.
结果：在研究期间，15例产前诊断。早期组的所有点的囊肿直径均显着较大。出生时囊肿直径>30毫米的患者，出生时肝内胆管扩张，出生后胆总管增大至>30mm更容易出现早期症状。血液生化测试显示两组之间没有显着差异。
结论：出生后早期囊肿直径>30mm的患者需要仔细的产后管理，父母应该被告知他们的孩子在出生后的头3个月内需要手术的可能性很高。
方法：四级。
