PDF(Pubmed)
Abstract：
Background: Supporting wellbeing beyond symptom reduction is necessary in trauma care. Research suggests increased posttraumatic growth (PTG) may promote wellbeing more effectively than posttraumatic stress disorder (PTSD) symptom reduction alone. Understanding neurobiological mechanisms of PTG would support PTG intervention development. However, most PTG research to-date has been cross-sectional data self-reported through surveys or interviews.Objective: Neural evidence of PTG and its coexistence with resilience and PTSD is limited. To advance neural PTG literature and contribute translational neuroscientific knowledge necessary to develop future objectively measurable neural-based PTG interventions.Method: Alpha frequency EEG and validated psychological inventories measuring PTG, resilience, and PTSD symptoms were collected from 30 trauma-exposed healthy adults amidst the COVID-19 pandemic. EEG data were collected using custom MNE-Python software, and a wireless OpenBCI 16-channel dry electrode EEG headset. Psychological inventory scores were analysed in SPSS Statistics and used to categorise the EEG data. Power spectral density analyses, t-tests and ANOVAs were conducted within EEGLab to identify brain activity differentiating high and low PTG, resilience, and PTSD symptoms.Results: Higher PTG was significantly differentiated from low PTG by higher alpha power in the left centro-temporal brain area around EEG electrode C3. A trend differentiating high PTG from PTSD was also indicated in this same location. Whole-scalp spectral topographies revealed alpha power EEG correlates of PTG, resilience and PTSD symptoms shared limited, but potentially meaningful similarities.Conclusion: This research provides the first comparative neural topographies of PTG, resilience and PTSD symptoms in the known literature. Results provide objective neural evidence supporting existing theory depicting PTG, resilience and PTSD as independent, yet co-occurring constructs. PTG neuromarker alpha C3 significantly delineated high from low PTG and warrants further investigation for potential clinical application. Findings provide foundation for future neural-based interventions and research for enhancing PTG in trauma-exposed individuals.
Objective translational study designed to increase neural understanding of posttraumatic growth (PTG) and provide a basis for future neural-based interventions to enhance PTG.Results provide neural evidence of PTG as an independent construct that coexists, and shares limited neural relatedness with resilience and PTSD symptoms.Increased PTG was significantly related to higher alpha power in the left centro-temporal brain area around EEG electrode C3: This finding warrants further investigation for potential clinical application.
Objective translational study designed to increase neural understanding of posttraumatic growth (PTG) and provide a basis for future neural-based interventions to enhance PTG.Results provide neural evidence of PTG as an independent construct that coexists, and shares limited neural relatedness with resilience and PTSD symptoms.Increased PTG was significantly related to higher alpha power in the left centro-temporal brain area around EEG electrode C3: This finding warrants further investigation for potential clinical application.
摘要：
背景：在创伤护理中，除了减轻症状外，还需要支持健康。研究表明，增加的创伤后生长（PTG）可能比仅减少创伤后应激障碍（PTSD）症状更有效地促进健康。了解PTG的神经生物学机制将支持PTG干预的发展。然而,迄今为止，大多数PTG研究都是通过调查或访谈自我报告的横断面数据。目的：PTG及其与弹性和PTSD共存的神经证据有限。推进神经PTG文献并贡献必要的转化神经科学知识，以开发未来客观可测量的基于神经的PTG干预措施。方法：Alpha频率脑电图和验证的心理清单测量PTG，弹性，在COVID-19大流行期间，从30名暴露于创伤的健康成年人中收集了PTSD症状。使用定制的MNE-Python软件收集脑电图数据，和无线OpenBCI16通道干电极脑电图耳机。在SPSSStatistics中分析了心理清单得分，并将其用于对EEG数据进行分类。功率谱密度分析,在EEGLab内进行t检验和方差分析，以鉴定区分高PTG和低PTG的大脑活动，弹性，和PTSD症状。结果：在EEG电极C3周围的左中央颞脑区域，较高的PTG与较低的PTG明显不同。在同一位置也表明了将高PTG与PTSD区分开的趋势。全头皮光谱形貌显示PTG的α功率EEG相关，弹性和创伤后应激障碍症状共享有限，但可能有意义的相似之处。结论：本研究提供了PTG的第一个比较神经拓扑，已知文献中的韧性和创伤后应激障碍症状。结果提供了客观的神经证据，支持描述PTG的现有理论，韧性和创伤后应激障碍是独立的，但同时发生的结构。PTG神经标记αC3明显与低PTG区分开来，值得进一步研究潜在的临床应用。研究结果为未来基于神经的干预措施和研究提供了基础，以增强创伤暴露个体的PTG。
目的转化研究旨在增加神经对创伤后生长（PTG）的理解，并为未来基于神经的干预措施提供基础，以增强PTG。结果提供了PTG作为共存的独立结构的神经证据，与弹性和创伤后应激障碍症状的神经相关性有限。PTG的增加与EEG电极C3周围左中央颞脑区域的较高α功率显着相关：这一发现值得进一步研究潜在的临床应用。
目的转化研究旨在增加神经对创伤后生长（PTG）的理解，并为未来基于神经的干预措施提供基础，以增强PTG。结果提供了PTG作为共存的独立结构的神经证据，与弹性和创伤后应激障碍症状的神经相关性有限。PTG的增加与EEG电极C3周围左中央颞脑区域的较高α功率显着相关：这一发现值得进一步研究潜在的临床应用。
