PDF(Pubmed)
Abstract：
The Dietary Inflammatory Index (DII) is designed to assess the inflammatory potential of the diet. While previous research has utilized DII among college-aged women, no study to date has validated it in this population. We conducted a construct validation of DII among 393 healthy women aged 18-31 years against a robust panel of 14 inflammatory biomarkers, including CRP, IL-1β, IL-4, IL-6, IL-10, and TNF-α, which were used in the development of DII. Three linear regression models were constructed: (1) an age-adjusted model, (2) the most parsimonious model based on likelihood ratio tests, and (3) a fully adjusted model for age, race, body mass index, waist circumference, physical activity, smoking status, and nonsteroidal anti-inflammatory drug use. DII was derived from the Harvard food frequency questionnaire and categorized into quartiles. Consistent with our hypothesis, DII was negatively and significantly associated with back-transformed IL-10 levels, confirming that a more pro-inflammatory diet was associated with lower levels of an anti-inflammatory cytokine (Model 3: Q4 vs. Q1 β = 0.62; 95% CI: 0.42, 0.93; p-trend = 0.04). While validated in other populations, DII may not be a suitable tool for assessing the inflammatory potential of the diet among college-aged women.
摘要：
饮食炎症指数（DII）旨在评估饮食的炎症潜力。虽然以前的研究已经在大学年龄的女性中使用了DII，迄今为止,尚无研究在该人群中验证.我们对393名年龄在18-31岁的健康女性进行了DII的构建验证，并对14种炎症生物标志物进行了验证。包括CRP,IL-1β,IL-4、IL-6、IL-10和TNF-α，用于DII的开发。构建了三个线性回归模型:(1)年龄调整模型,(2)基于似然比检验的最简约模型,和(3)一个完全调整的年龄模型，种族,身体质量指数,腰围,身体活动,吸烟状况,和非甾体抗炎药的使用。DII来自哈佛食物频率问卷，并分为四分位数。与我们的假设一致，DII与反向转化的IL-10水平呈负相关且显着相关，证实更多的促炎饮食与较低水平的抗炎细胞因子相关(模型3：Q4与Q1β=0.62；95%CI：0.42，0.93；p趋势=0.04）。虽然在其他人群中得到了验证，DII可能不是评估大学女性饮食炎症潜力的合适工具。
