PDF(Pubmed)
Abstract：
Metabolic syndrome (MS) is a growing social, economic, and health problem. MS coexists with nearly half of all patients with affective disorders. This study aimed to evaluate the neurobiological parameters (clinical, anthropometric, biochemical, adipokines levels, and ultrasound of carotid arteries) and their relationship with the development of MS in patients with bipolar disorder. The study group consisted of 70 patients (50 women and 20 men) hospitalized due to episodes of depression in the course of bipolar disorders. The Hamilton Depression Rating Scale was used to assess the severity of the depression symptoms in an acute state of illness and after six weeks of treatment. The serum concentration of adipokines was determined using an ELISA method. The main finding of this study is that the following adipokines correlated with MS in the bipolar depression women group: visfatin, S100B, and leptin had a positive correlation, whereas adiponectin, leptin-receptor, and adiponectin/leptin ratio showed a negative correlation. Moreover, the adiponectin/leptin ratio showed moderate to strong negative correlation with insulin level, BMI, waist circumference, triglyceride level, treatment with metformin, and a positive moderate correlation with HDL. The adiponectin/leptin ratio may be an effective tool to assess MS in depressed female bipolar patients.
摘要：
代谢综合征（MS）是一种日益增长的社会，经济,和健康问题。MS与近一半的情感障碍患者共存。本研究旨在评估神经生物学参数(临床，人体测量学,生物化学，脂肪因子水平,和颈动脉超声）及其与双相情感障碍患者MS发展的关系。研究组由70名患者（50名女性和20名男性）在双相情感障碍过程中因抑郁发作而住院。汉密尔顿抑郁量表用于评估急性疾病状态下和治疗六周后抑郁症状的严重程度。使用ELISA方法测定脂肪因子的血清浓度。这项研究的主要发现是，在双相抑郁女性组中，以下脂肪因子与MS相关：visfatin，S100B,与瘦素呈正相关,而脂联素，瘦素受体,与脂联素/瘦素比值呈负相关。此外，脂联素/瘦素比值与胰岛素水平呈中强负相关,BMI,腰围,甘油三酯水平，用二甲双胍治疗，与HDL呈正相关。脂联素/瘦素比值可能是评估女性双相抑郁患者MS的有效工具。
