PDF(Pubmed)
Abstract：
The growing concern regarding the adverse effects of synthetic UV filters found in sunscreens has spurred significant attention due to their potential harm to aquatic ecosystems and human health. To address this, the present study aimed to extract and microencapsulate sensitive bioactive compounds derived from by-product onion peel (OP) by molecular inclusion using β-cyclodextrin as the wall material. Identification and quantification of bioactive compounds within the extract were conducted through high-performance liquid chromatography (HPLC-DAD) analysis, revealing quercetin and resveratrol as the primary constituents. The photoprotection capacity, evaluated by the sun protection factor (SPF), revealed a protection factor comparable to the value for a synthetic UV filter. The produced microparticles presented high antioxidant capacity, significant photoprotection capacity, encapsulation efficiency of 91.8%, mean diameter of 31 μm, and polydispersity of 2.09. Furthermore, to comprehensively evaluate the performance of OP extract and its potential as a natural UV filter, five O/W emulsions were produced. Results demonstrated that microparticles displayed superior ability in maintaining SPF values over a five-week period. Photoprotection evaluation-skin reactivity tests revealed that both extract and microparticles absorb UV radiation in other regions of UV radiation, revealing their potential to be used as a natural UV filter to produce a sustainable and eco-friendly value-added sunscreen.
摘要：
对防晒剂中发现的合成紫外线过滤剂的不利影响的日益关注已经引起了人们的极大关注,因为它们对水生生态系统和人类健康的潜在危害。为了解决这个问题，本研究旨在使用β-环糊精作为壁材，通过分子包合从副产品洋葱皮（OP）中提取和微囊化敏感的生物活性化合物。通过高效液相色谱（HPLC-DAD）分析，对提取物中的生物活性化合物进行鉴定和定量。显示槲皮素和白藜芦醇为主要成分。光保护能力，通过防晒系数(SPF)评估，揭示了与合成紫外线过滤器的值相当的保护系数。产生的微粒呈现高抗氧化能力，显著的光保护能力，封装效率为91.8%，平均直径31μm，和多分散性为2.09。此外，为了全面评估OP提取物的性能及其作为天然紫外线过滤剂的潜力，生产了五种O/W乳液。结果表明,微粒在五周的时间内显示出优异的维持SPF值的能力。光保护评估-皮肤反应性测试表明，提取物和微粒在其他紫外线辐射区域吸收紫外线辐射，揭示了它们作为天然紫外线过滤剂的潜力，以生产可持续和生态友好的增值防晒霜。
