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Abstract：
We performed a systematic evaluation of the diagnostic performance of LAFOV PET/CT with increasing acquisition time. The first 100 oncologic adult patients referred for 3 MBq/kg 2-[18F]fluoro-2-deoxy-D-glucose PET/CT on the Siemens Biograph Vision Quadra were included. A standard imaging protocol of 10 min was used and scans were reconstructed at 30 s, 60 s, 90 s, 180 s, 300 s, and 600 s. Paired comparisons of quantitative image noise, qualitative image quality, lesion detection, and lesion classification were performed. Image noise (n = 50, 34 women) was acceptable according to the current standard of care (coefficient-of-varianceref < 0.15) after 90 s and improved significantly with increasing acquisition time (PB < 0.001). The same was seen in observer rankings (PB < 0.001). Lesion detection (n = 100, 74 women) improved significantly from 30 s to 90 s (PB < 0.001), 90 s to 180 s (PB = 0.001), and 90 s to 300 s (PB = 0.002), while lesion classification improved from 90 s to 180 s (PB < 0.001), 180 s to 300 s (PB = 0.021), and 90 s to 300 s (PB < 0.001). We observed improved image quality, lesion detection, and lesion classification with increasing acquisition time while maintaining a total scan time of less than 5 min, which demonstrates a potential clinical benefit. Based on these results we recommend a standard imaging acquisition protocol for LAFOV PET/CT of minimum 180 s to maximum 300 s after injection of 3 MBq/kg 2-[18F]fluoro-2-deoxy-D-glucose.
摘要：
随着采集时间的增加，我们对LAFOVPET/CT的诊断性能进行了系统评估。包括在SiemensBiographVisionQuadra上提及3MBq/kg2-[18F]氟-2-脱氧-D-葡萄糖PET/CT的前100名肿瘤成年患者。使用10分钟的标准成像方案，并在30s时重建扫描，60s,90s,180s,300s,和600秒。定量图像噪声的配对比较，定性图像质量，病变检测,并进行病变分类。图像噪声（n=50，34名女性）在90s后根据当前的护理标准（变异系数<0.15）是可以接受的，并且随着采集时间的增加（PB<0.001）显着改善。观察者排名也是如此（PB<0.001）。病变检测（n=100，74名妇女）从30s到90s（PB<0.001）显着改善，90s至180s(PB=0.001)，90s到300s(PB=0.002)，病变分类从90s提高到180s(PB<0.001)，180s至300s(PB=0.021)，90秒至300秒(PB<0.001)。我们观察到图像质量得到改善，病变检测,和病变分类增加采集时间，同时保持总扫描时间小于5分钟，这证明了潜在的临床益处。根据这些结果，我们建议在注射3MBq/kg2-[18F]氟-2-脱氧-D-葡萄糖后，最低180s至最高300s的LAFOVPET/CT标准成像采集方案。
