Abstract：
Cancer is one of the significant issues with public health and the second leading cause of death worldwide. The three most lethal cancers in the general population are stomach, lung, and liver cancers, in which lung and breast cancers cause the majority of cancer-associated deaths among men and women, respectively. CeO2 nanoparticles have a cytoprotectant effect in normal cells and a cytotoxic effect in cancer cells that enables them to induce the reactive oxygen species (ROS) production within cancer cells, which in turn develops reactive nitrogen species (RNS) that interfere with intracellular activities, and this property makes them an excellent anticancer agent. Because of its biofilm suppression, free radical scavenging ability, redox activity, and other unique properties, attention has been bestowed on cerium oxide nanoparticles as a potential alternative to solve many biomedical issues in the future. This review mainly focuses on the combinatorial effect of cerium dioxide nanoparticles and Doxorubicin in cancer management.
摘要：
癌症是公共卫生的重要问题之一，也是全球第二大死亡原因。普通人群中三种最致命的癌症是胃癌，肺，和肝癌，其中肺癌和乳腺癌导致大多数男性和女性癌症相关死亡，分别。CeO2纳米颗粒在正常细胞中具有细胞保护剂作用，在癌细胞中具有细胞毒性作用，使它们能够诱导癌细胞内活性氧（ROS）的产生。进而产生干扰细胞内活动的活性氮物种（RNS），这种特性使它们成为优秀的抗癌剂。由于其生物膜抑制作用，自由基清除能力，氧化还原活性，和其他独特的属性，作为未来解决许多生物医学问题的潜在替代品，氧化铈纳米颗粒受到了广泛的关注。本文主要对纳米二氧化铈和阿霉素在肿瘤治疗中的联合作用进行综述。
