Abstract：
OBJECTIVE: Previous research has shown that low birth weight is one of the risk factors for esophageal atresia. However, there remains a paucity of evidence on the timing and the treatment method.
METHODS: Data were collected using a multi-institutional observational study in 11 hospitals that performed surgeries on esophageal atresia babies whose birth weights were ≤1500 g from 2001 to 2020.
RESULTS: Of the 46 patients analyzed, median birth weight was 1233 (IQR 1042-1412) g. Within 46 cases, 19 (41%) underwent definitive esophageal anastomosis at the median of age in 8 (IQR 2-101) days. Thirteen out of 19 experienced either closure of tracheoesophageal fistula, gastrostomy, or esophageal banding at the first operation, followed by esophageal anastomosis. Seven infants, including four cases of <1000 g, underwent anastomosis after one month of age to wait for weight gain (variously 2-3000 g). Twenty-one out of 27 infants (78%) who did not receive anastomosis died within one year of age, including 21 (78 %) with major cardiac anomalies and 24 (89%) with severe chromosomal anomalies (trisomy 18). Six survivors in this group, all with trisomy 18, lived with palliative surgical treatments.
CONCLUSIONS: In our study, the definitive esophageal anastomosis was effective either at the first operation or as a later treatment after gaining weight. Although having severe anomalies, some infants receive palliative surgical treatments, and the next surgery was considered depending on their condition.
METHODS: II.
METHODS: Data were collected using a multi-institutional observational study in 11 hospitals that performed surgeries on esophageal atresia babies whose birth weights were ≤1500 g from 2001 to 2020.
RESULTS: Of the 46 patients analyzed, median birth weight was 1233 (IQR 1042-1412) g. Within 46 cases, 19 (41%) underwent definitive esophageal anastomosis at the median of age in 8 (IQR 2-101) days. Thirteen out of 19 experienced either closure of tracheoesophageal fistula, gastrostomy, or esophageal banding at the first operation, followed by esophageal anastomosis. Seven infants, including four cases of <1000 g, underwent anastomosis after one month of age to wait for weight gain (variously 2-3000 g). Twenty-one out of 27 infants (78%) who did not receive anastomosis died within one year of age, including 21 (78 %) with major cardiac anomalies and 24 (89%) with severe chromosomal anomalies (trisomy 18). Six survivors in this group, all with trisomy 18, lived with palliative surgical treatments.
CONCLUSIONS: In our study, the definitive esophageal anastomosis was effective either at the first operation or as a later treatment after gaining weight. Although having severe anomalies, some infants receive palliative surgical treatments, and the next surgery was considered depending on their condition.
METHODS: II.
摘要：
目的：先前的研究表明，低出生体重是食管闭锁的危险因素之一。然而,关于时机和治疗方法的证据仍然很少。
方法：在2001年至2020年对出生体重≤1500g的食管闭锁婴儿进行手术的11家医院进行了多机构观察研究，收集了数据。
结果：在分析的46例患者中，中位出生体重为1233(IQR1042-1412)g。46例中，19（41％）在8（IQR2-101）天的中位年龄进行了确定性食管吻合术。19人中有13人经历了气管食管瘘的闭合，胃造口术,或者第一次手术的食管绑扎，其次是食管吻合术。七个婴儿,包括四例<1000g，一个月后接受吻合术等待体重增加（不同2-3000克）。未接受吻合的27名婴儿中有21名（78％）在一年内死亡，包括21（78％）患有严重心脏异常和24（89％）患有严重染色体异常（18三体）。这群人中有六个幸存者，都患有18三体，接受姑息性手术治疗。
结论：在我们的研究中，明确的食管吻合术在第一次手术或体重增加后的后期治疗中均有效。虽然有严重的异常,一些婴儿接受姑息性手术治疗，根据他们的情况考虑下一次手术。
方法：II.
方法：在2001年至2020年对出生体重≤1500g的食管闭锁婴儿进行手术的11家医院进行了多机构观察研究，收集了数据。
结果：在分析的46例患者中，中位出生体重为1233(IQR1042-1412)g。46例中，19（41％）在8（IQR2-101）天的中位年龄进行了确定性食管吻合术。19人中有13人经历了气管食管瘘的闭合，胃造口术,或者第一次手术的食管绑扎，其次是食管吻合术。七个婴儿,包括四例<1000g，一个月后接受吻合术等待体重增加（不同2-3000克）。未接受吻合的27名婴儿中有21名（78％）在一年内死亡，包括21（78％）患有严重心脏异常和24（89％）患有严重染色体异常（18三体）。这群人中有六个幸存者，都患有18三体，接受姑息性手术治疗。
结论：在我们的研究中，明确的食管吻合术在第一次手术或体重增加后的后期治疗中均有效。虽然有严重的异常,一些婴儿接受姑息性手术治疗，根据他们的情况考虑下一次手术。
方法：II.
