Abstract：
The 20th century unfolded many mysteries regarding renal pathology with the advent of ancillary techniques such as immunofluorescence (IF) and electron microscopy (EM) studies. EM plays a major role in confirming the routine and IF findings or may uncover new and unsuspected features. The aim of the study is to elucidate the role of ultrastructural findings in patients with medical kidney diseases on whom kidney biopsy was performed at the American University of Beirut Medical Center, between November 2018 and June 2019. A total of 188 renal biopsies were examined during the study period. EM confirmed the light microscopy diagnosis in 54% of the cases while completely changed the diagnosis in 23% of the cases. In 23% of the sample, EM provided additional features and a secondary diagnosis. Our study emphasizes the important diagnostic role of EM and its significance, particularly in minimal change disease, basement membrane abnormalities, and glomerulopathies.
摘要：
随着免疫荧光（IF）和电子显微镜（EM）研究等辅助技术的出现，20世纪展开了许多有关肾脏病理学的谜团。EM在确认常规和IF发现中起着重要作用，或者可能发现新的和未怀疑的特征。该研究的目的是阐明超微结构发现在贝鲁特美国大学医学中心进行肾脏活检的医学肾脏疾病患者中的作用。2018年11月至2019年6月。在研究期间共检查了188例肾活检。EM在54％的病例中证实了光学显微镜诊断，而在23％的病例中完全改变了诊断。在23%的样本中，EM提供了额外的功能和辅助诊断。我们的研究强调了EM的重要诊断作用及其意义，特别是在微小变化疾病中，基底膜异常，和肾小球疾病。
